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Tbio
BBX
HMG box transcription factor BBX

Protein Summary
Description
Transcription factor that is necessary for cell cycle progression from G1 to S phase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325805
  • ENSP00000319974
  • ENSG00000114439
  • ENST00000406780
  • ENSP00000385530
  • ENST00000415149
  • ENSP00000408358
  • ENST00000416476
  • ENSP00000403860

Symbol
  • HBP2
  • HBP2
  • ARTC1
  • MDS001
  • HSPC339
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
trait
0.97
microRNA
0.83
transcription factor
0.75
PubMedID
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.74   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.74   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
CHIC1
Tdark
Novelty:  0.06718561
p_int:  0.997982654
p_ni:  0.002017346
Data Source:  BioPlex
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.997779818
p_ni:  0.002220179
p_wrong:  2e-9
Data Source:  BioPlex
SCGN
Tbio
Novelty:  0.01434518
p_int:  0.993705745
p_ni:  0.006294253
p_wrong:  2e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
RPS13
Tbio
Novelty:  0.0019983
p_int:  0.992992556
p_ni:  0.007007444
Data Source:  BioPlex
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.950045365
p_ni:  0.049954635
Data Source:  BioPlex
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.945497964
p_ni:  0.054450668
p_wrong:  0.000051368
Data Source:  BioPlex
GPATCH4
Tdark
Novelty:  1.13040547
p_int:  0.938415089
p_ni:  0.061552459
p_wrong:  0.000032452
Data Source:  BioPlex
ZNF512
Tbio
Family:  TF
Novelty:  0.08783629
p_int:  0.92944435
p_ni:  0.070555158
p_wrong:  4.92e-7
Data Source:  BioPlex
ZNF653
Tbio
Family:  TF
Novelty:  1.467544
p_int:  0.928766518
p_ni:  0.071228831
p_wrong:  0.000004651
Data Source:  BioPlex
NIFK
Tbio
Novelty:  0.01221562
p_int:  0.909155802
p_ni:  0.09023426
p_wrong:  0.000609938
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
81.6
neuroticism measurement
3
8
2
6.4
76.1
calcium measurement
1
2
2
75.9
myeloid white cell count
1
1
1
74.8
mean platelet volume
2
2
2
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
81.6
neuroticism measurement
2
6.4
76.1
calcium measurement
2
75.9
myeloid white cell count
1
74.8
mean platelet volume
2
74
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BBX, HMG-box containing
VGNC:13001
470876
Mouse
MGI:1917758
70508
Rat
RGD:1309769
303970
Dog
BBX, HMG-box containing
VGNC:38394
478551
Horse
BBX, HMG-box containing
VGNC:15778
100061782
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BBX, HMG-box containing
Mouse
Rat
Dog
BBX, HMG-box containing
Horse
BBX, HMG-box containing
Publication Statistics
PubMed Score 65.74
PubMed score by year
PubTator Score 13.81
PubTator score by year
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Related Publications
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PMID
Year
Title