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Tbio
SORCS1
VPS10 domain-containing receptor SorCS1

Protein Classes
Protein Summary
Description
This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
microRNA
0.95
tissue sample
0.61
disease
0.59
cell line
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.91   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.91   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (10)
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Ectoderm Differentiation
WikiPathways
Ectoderm Differentiation
WikiPathways
Ectoderm Differentiation
WikiPathways
Dopaminergic Neurogenesis
WikiPathways
Endoderm Differentiation
Name
Explore in Pharos
Explore in Source
Ectoderm Differentiation
Ectoderm Differentiation
Ectoderm Differentiation
Dopaminergic Neurogenesis
Endoderm Differentiation
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (43)
1 – 10 of 43
VPS35
Tbio
Novelty: 0.00729892
Score: 0.829
Data Source: STRINGDB
VPS26A
Tbio
Novelty: 0.01804654
Score: 0.754
Data Source: STRINGDB
APP
Tchem
Novelty: 0.00008964
Score: 0.746
Data Source: STRINGDB
VPS29
Tbio
Novelty: 0.01335106
Score: 0.668
Data Source: STRINGDB
TTC13
Tdark
Novelty: 2.24743499
Score: 0.663
Data Source: STRINGDB
CELSR2
Tbio
Family: GPCR
Novelty: 0.02657319
Score: 0.658
Data Source: STRINGDB
ZFP69
Tdark
Family: TF
Novelty: 0.45110932
Score: 0.644
Data Source: STRINGDB
PSRC1
Tbio
Novelty: 0.02780308
Score: 0.641
Data Source: STRINGDB
VPS26B
Tdark
Novelty: 0.25702869
Score: 0.638
Data Source: STRINGDB
SORT1
Tchem
Novelty: 0.00319862
Score: 0.575
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.91

PubMed score by year
PubTator Score  20.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer