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Tbio
ADAMTS14
A disintegrin and metalloproteinase with thrombospondin motifs 14

Protein Classes
Protein Summary
Description
Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373207
  • ENSP00000362303
  • ENSG00000138316
  • ENST00000373208
  • ENSP00000362304
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.67
cell line
0.64
phenotype
0.61
trait
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.11   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.11   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
2
4
97.2
body fat distribution
2
1
4
51
heel bone mineral density
1
1
1
30.4
optic disc size measurement
1
1
1
20.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
97.2
body fat distribution
4
51
heel bone mineral density
1
30.4
optic disc size measurement
1
20.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 14
VGNC:3795
450513
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 14
710154
Mouse
MGI:2179942
237360
Rat
RGD:1308899
309837
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 14
VGNC:37593
489031
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 14
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 14
Mouse
Rat
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 14
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WXS8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen formation
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (71)
1 – 10 of 71
COL5A3
Tbio
Novelty: 0.06365591
Score: 0.96
Data Source: STRINGDB
COL1A2
Tbio
Novelty: 0.00048334
Score: 0.935
Data Source: STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
Score: 0.93
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
Score: 0.924
Data Source: STRINGDB
COL11A1
Tbio
Novelty: 0.00594683
Score: 0.923
Data Source: STRINGDB
ADAMTS13
Tbio
Family: Enzyme
Novelty: 0.0006095
Score: 0.923
Data Source: STRINGDB
ADAMTS12
Tbio
Family: Enzyme
Novelty: 0.03184816
Score: 0.922
Data Source: STRINGDB
ADAMTS20
Tbio
Family: Enzyme
Novelty: 0.0416108
Score: 0.922
Data Source: STRINGDB
COL2A1
Tbio
Novelty: 0.0011102
Score: 0.921
Data Source: STRINGDB
ADAMTS15
Tbio
Family: Enzyme
Novelty: 0.09715925
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.11

PubMed score by year
PubTator Score  13.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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