ADAMTS14
A disintegrin and metalloproteinase with thrombospondin motifs 14
Protein Summary
Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016]
- ENST00000373207
- ENSP00000362303
- ENSG00000138316
- ENST00000373208
- ENSP00000362304
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
histone modification site profile | 0.67 | ||
cell line | 0.64 | ||
phenotype | 0.61 | ||
trait | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.77 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 35 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.77 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 35 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (71)
Nearest Tclin Targets
Pathways (11)
Reactome (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Collagen biosynthesis and modifying enzymes | ||||
Reactome | Collagen formation | ||||
Reactome | Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Collagen biosynthesis and modifying enzymes | ||||
Collagen formation | ||||
Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 3 | 5 | 9 | 95.1 | |||||
lymphocyte count | 1 | 1 | 1 | 78.4 | |||||
lymphocyte percentage of leukocytes | 2 | 2 | 2 | 74.8 | |||||
body fat distribution | 2 | 1 | 4 | 61 | |||||
heel bone mineral density | 2 | 2 | 2 | 48.5 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
appendicular lean mass | 9 | 95.1 | |||||
lymphocyte count | 1 | 78.4 | |||||
lymphocyte percentage of leukocytes | 2 | 74.8 | |||||
body fat distribution | 4 | 61 | |||||
heel bone mineral density | 2 | 48.5 | |||||
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IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ADAM metallopeptidase with thrombospondin type 1 motif 14 | VGNC:3795 | 450513 | |||||
Macaque | ADAM metallopeptidase with thrombospondin type 1 motif 14 | 710154 | ||||||
Mouse | MGI:2179942 | 237360 | ||||||
Rat | RGD:1308899 | 309837 | ||||||
Dog | ADAM metallopeptidase with thrombospondin type 1 motif 14 | VGNC:37593 | 489031 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ADAM metallopeptidase with thrombospondin type 1 motif 14 | |||||
Macaque | ADAM metallopeptidase with thrombospondin type 1 motif 14 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ADAM metallopeptidase with thrombospondin type 1 motif 14 | |||||
Publication Statistics
PubMed Score 12.77
PubMed score by year
PubTator Score 13.73
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (11)
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0 of 0
PMID | Year | Title |
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