ADAMTS14
A disintegrin and metalloproteinase with thrombospondin motifs 14
Protein Classes
Protein Summary
Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016]
- ENST00000373207
- ENSP00000362303
- ENSG00000138316
- ENST00000373208
- ENSP00000362304
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
histone modification site profile | 0.67 | ||
cell line | 0.64 | ||
phenotype | 0.61 | ||
trait | 0.61 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.11 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 35 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.11 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 35 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 2 | 2 | 4 | 97.2 | |||||
body fat distribution | 2 | 1 | 4 | 51 | |||||
heel bone mineral density | 1 | 1 | 1 | 30.4 | |||||
optic disc size measurement | 1 | 1 | 1 | 20.3 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
appendicular lean mass | 4 | 97.2 | |||||
body fat distribution | 4 | 51 | |||||
heel bone mineral density | 1 | 30.4 | |||||
optic disc size measurement | 1 | 20.3 | |||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ADAM metallopeptidase with thrombospondin type 1 motif 14 | VGNC:3795 | 450513 | |||||
Macaque | ADAM metallopeptidase with thrombospondin type 1 motif 14 | 710154 | ||||||
Mouse | MGI:2179942 | 237360 | ||||||
Rat | RGD:1308899 | 309837 | ||||||
Dog | ADAM metallopeptidase with thrombospondin type 1 motif 14 | VGNC:37593 | 489031 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ADAM metallopeptidase with thrombospondin type 1 motif 14 | |||||
Macaque | ADAM metallopeptidase with thrombospondin type 1 motif 14 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ADAM metallopeptidase with thrombospondin type 1 motif 14 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (11)
Reactome (11)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 11
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Collagen biosynthesis and modifying enzymes | ||||
Reactome | Collagen formation | ||||
Reactome | Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Collagen biosynthesis and modifying enzymes | ||||
Collagen formation | ||||
Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
Gene Ontology Terms (5)
Functions (2)
Components (1)
Processes (2)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (71)
1 – 10 of 71
COL5A3
Novelty: 0.06365591
Score: 0.96
Data Source: STRINGDB
COL1A2
Novelty: 0.00048334
Score: 0.935
Data Source: STRINGDB
COL5A1
Novelty: 0.00506815
Score: 0.93
Data Source: STRINGDB
COL1A1
Novelty: 0.00063584
Score: 0.924
Data Source: STRINGDB
COL11A1
Novelty: 0.00594683
Score: 0.923
Data Source: STRINGDB
ADAMTS13
Family: Enzyme
Novelty: 0.0006095
Score: 0.923
Data Source: STRINGDB
ADAMTS12
Family: Enzyme
Novelty: 0.03184816
Score: 0.922
Data Source: STRINGDB
ADAMTS20
Family: Enzyme
Novelty: 0.0416108
Score: 0.922
Data Source: STRINGDB
COL2A1
Novelty: 0.0011102
Score: 0.921
Data Source: STRINGDB
ADAMTS15
Family: Enzyme
Novelty: 0.09715925
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score 12.11
PubMed score by year
PubTator Score 13.73
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword
GWAS Trait