ADAMTS14
A disintegrin and metalloproteinase with thrombospondin motifs 14
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.92 | ||
histone modification site profile | 0.67 | ||
cell line | 0.64 | ||
phenotype | 0.61 | ||
trait | 0.61 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Collagen biosynthesis and modifying enzymes | ||||
Reactome | Collagen formation | ||||
Reactome | Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Collagen biosynthesis and modifying enzymes | ||||
Collagen formation | ||||
Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 3 | 5 | 9 | 95.1 | |||||
lymphocyte count | 1 | 1 | 1 | 78.4 | |||||
lymphocyte percentage of leukocytes | 2 | 2 | 2 | 74.8 | |||||
body fat distribution | 2 | 1 | 4 | 61 | |||||
heel bone mineral density | 2 | 2 | 2 | 48.5 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
appendicular lean mass | 9 | 95.1 | |||||
lymphocyte count | 1 | 78.4 | |||||
lymphocyte percentage of leukocytes | 2 | 74.8 | |||||
body fat distribution | 4 | 61 | |||||
heel bone mineral density | 2 | 48.5 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ADAM metallopeptidase with thrombospondin type 1 motif 14 | VGNC:3795 | 450513 | |||||
Macaque | ADAM metallopeptidase with thrombospondin type 1 motif 14 | 710154 | ||||||
Mouse | MGI:2179942 | 237360 | ||||||
Rat | RGD:1308899 | 309837 | ||||||
Dog | ADAM metallopeptidase with thrombospondin type 1 motif 14 | VGNC:37593 | 489031 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | ADAM metallopeptidase with thrombospondin type 1 motif 14 | |||||
Macaque | ADAM metallopeptidase with thrombospondin type 1 motif 14 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ADAM metallopeptidase with thrombospondin type 1 motif 14 | |||||
PMID | Year | Title |
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