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Tdark
CACNG8
Voltage-dependent calcium channel gamma-8 subunit

Protein Summary
Description
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefS ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000638874
  • ENSP00000492637
  • ENSG00000142408

Symbol
  • CACNG6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
microRNA
0.61
tissue sample
0.58
cellular component
0.55
kinase perturbation
0.48


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.72   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.72   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit gamma 8 [Source:HGNC Symbol;Acc:HGNC:13628]
Mouse
MGI:1932376
81905
Rat
RGD:628808
140729
Dog
calcium voltage-gated channel auxiliary subunit gamma 8
VGNC:38652
611498
Cow
calcium voltage-gated channel auxiliary subunit gamma 8
VGNC:52183
100313457
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit gamma 8 [Source:HGNC Symbol;Acc:HGNC:13628]
Mouse
Rat
Dog
calcium voltage-gated channel auxiliary subunit gamma 8
Cow
calcium voltage-gated channel auxiliary subunit gamma 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WXS5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome
LGI-ADAM interactions
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Developmental Biology
Glutamate binding, activation of AMPA receptors and synaptic plasticity
LGI-ADAM interactions
Muscle contraction
Protein-Protein Interactions (147)
1 – 10 of 147
CACNB1
Tbio
Family: IC
Novelty: 0.06568749
Score: 0.963
Data Source: STRINGDB
CACNA1D
Tclin
Family: IC
Novelty: 0.00314752
Score: 0.961
Data Source: STRINGDB
GRIA1
Tclin
Family: IC
Novelty: 0.0005008
Score: 0.957
Data Source: STRINGDB
CACNA2D1
Tclin
Family: IC
Novelty: 0.01744541
Score: 0.954
Data Source: STRINGDB
CACNB2
Tbio
Family: IC
Novelty: 0.01745218
Score: 0.946
Data Source: STRINGDB
CACNA2D2
Tclin
Family: IC
Novelty: 0.02041017
Score: 0.946
Data Source: STRINGDB
CACNB4
Tbio
Family: IC
Novelty: 0.01564026
Score: 0.943
Data Source: STRINGDB
GRIA4
Tclin
Family: IC
Novelty: 0.00284417
Score: 0.934
Data Source: STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.933
Data Source: Reactome,STRINGDB
CACNG7
Tdark
Family: IC
Novelty: 0.32460059
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.72

PubMed score by year
PubTator Score  1.71

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer