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Tbio
MYO3B
Myosin-IIIb

Protein Summary
Description
Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments. This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317935
  • ENSP00000314650
  • ENSG00000071909
  • ENST00000408978
  • ENSP00000386213
  • ENST00000409044
  • ENSP00000386497
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.97
trait
0.86
gene perturbation
0.81
tissue sample
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.01   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.01   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
2
2
95.2
mathematical ability
4
2
4
93.2
balding measurement
1
1
1
48.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
95.2
mathematical ability
4
93.2
balding measurement
1
48.8
Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cytoskeletal regulation by Rho GTPase
PathwayCommons: panther
Inflammation mediated by chemokine and cytokine signaling pathway
PathwayCommons: panther
Nicotinic acetylcholine receptor signaling pathway
Name
Explore in Pharos
Explore in Source
Cytoskeletal regulation by Rho GTPase
Inflammation mediated by chemokine and cytokine signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (82)
1 – 10 of 82
TNNC1
Tclin
Novelty: 0.03535727
p_int: 0.969654657
p_ni: 0.030328796
p_wrong: 0.000016547
Score: 0.273
Data Source: BioPlex,STRINGDB
MYL12B
Tbio
Novelty: 0.00999083
p_int: 0.964997976
p_ni: 0.034958276
p_wrong: 0.000043748
Score: 0.285
Data Source: BioPlex,STRINGDB
ESPN
Tbio
Novelty: 0.0035928
Score: 0.919
Data Source: STRINGDB
OR3A3
Tdark
Family: oGPCR
Novelty: 2.16748768
Score: 0.812
Data Source: STRINGDB
MORN4
Tdark
Novelty: 0.22826325
Score: 0.812
Data Source: STRINGDB
OR4K17
Tdark
Family: oGPCR
Novelty: 3.64365411
Score: 0.794
Data Source: STRINGDB
OR3A2
Tdark
Family: oGPCR
Novelty: 1.6204251
Score: 0.773
Data Source: STRINGDB
ZC3H12C
Tdark
Family: Enzyme
Novelty: 0.36746246
Score: 0.713
Data Source: STRINGDB
SLC2A9
Tbio
Family: Transporter
Novelty: 0.00683926
Score: 0.679
Data Source: STRINGDB
JPH1
Tbio
Novelty: 0.00931679
Score: 0.675
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.01

PubMed score by year
PubTator Score  5.95

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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