You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
ASB13
Ankyrin repeat and SOCS box protein 13

Protein Summary
Description
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357700
  • ENSP00000350331
  • ENSG00000196372
  • ENST00000459912
  • ENSP00000433358
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
histone modification site profile
0.85
tissue sample
0.7
transcription factor perturbation
0.61
small molecule perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.66   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.66   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
47.7
waist-hip ratio
1
1
1
36.5
systolic blood pressure
1
1
1
17.8
age at menopause
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
47.7
waist-hip ratio
1
36.5
systolic blood pressure
1
17.8
age at menopause
1
15.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and SOCS box containing 13
VGNC:11639
737798
Macaque
ankyrin repeat and SOCS box containing 13
712298
Mouse
MGI:2145525
142688
Rat
RGD:1310387
361268
Dog
ankyrin repeat and SOCS box containing 13
VGNC:52211
608587
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and SOCS box containing 13
Macaque
ankyrin repeat and SOCS box containing 13
Mouse
Rat
Dog
ankyrin repeat and SOCS box containing 13
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WXK3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (310)
1 – 10 of 310
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.999993331
p_ni:  2e-9
p_wrong:  0.000006667
Score:  0.937
Data Source:  BioPlex,STRINGDB
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.991428653
p_ni:  0.008571347
Score:  0.317
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.972823871
p_ni:  4.9e-8
p_wrong:  0.02717608
Score:  0.913
Data Source:  BioPlex,STRINGDB
MGRN1
Tbio
Family:  Enzyme
Novelty:  0.04981605
Score:  0.939
Data Source:  STRINGDB
TRIM11
Tbio
Family:  Enzyme
Novelty:  0.02243955
Score:  0.934
Data Source:  STRINGDB
ARIH2
Tbio
Family:  Enzyme
Novelty:  0.03455224
Score:  0.934
Data Source:  STRINGDB
KLHL20
Tbio
Novelty:  0.12205871
Score:  0.93
Data Source:  STRINGDB
ASB7
Tdark
Novelty:  0.21883348
Score:  0.929
Data Source:  STRINGDB
ASB2
Tbio
Novelty:  0.02852942
Score:  0.929
Data Source:  STRINGDB
ASB1
Tdark
Novelty:  0.0931554
Score:  0.929
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.66

PubMed score by year
PubTator Score  0.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer