GATAD2B
Transcriptional repressor p66-beta
Protein Summary
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development. This gene encodes a zinc finger protein transcriptional repressor. The encoded protein is part of the methyl-CpG-binding protein-1 complex, which represses gene expression by deacetylating methylated nucleosomes. Mutations in this gene are linked to intellectual disability and dysmorphic features associated with cognitive disability. [provided by RefSeq, Jun 2016]
- ENST00000368655
- ENSP00000357644
- ENSG00000143614
- ENST00000576342
- ENSP00000458280
- ENSG00000261992
- ENST00000634544
- ENSP00000489184
- KIAA1150
- p68
- MRD18
- P66beta
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
microRNA | 0.86 | ||
interacting protein | 0.8 | ||
protein complex | 0.74 | ||
drug perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.89 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 262 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.89 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 262 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0