Tbio CLEC4D C-type lectin domain family 4 member D

Protein Summary

Description

A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766). Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells (PubMed:14971047). This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WXI8
• Q8N5J5

Gene Name

• CLEC4D

Ensembl ID

• ENST00000299665
• ENSP00000299665
• ENSG00000166527

Symbol

• CLECSF8
• MCL
• MCL
• MPCL
• CD368
• CLEC6
• CLEC-6
• CLECSF8
• Dectin-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.73
virus perturbation	0.72
gene perturbation	0.68
tissue	0.59
microRNA	0.54

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / C-type Lectin Domain Family 4 Member D

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / C-type Lectin Domain Family 4 Member D

Protein / Cell Adhesion Molecule / C-type Lectin Domain Family 4 Member D

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / C-type Lectin Domain Family 4 Member D

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.93   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 256   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.93   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0