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Tbio
CLEC4D
C-type lectin domain family 4 member D

Protein Summary
Description
A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766). Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells (PubMed:14971047). This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family sh ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299665
  • ENSP00000299665
  • ENSG00000166527

Symbol
  • CLECSF8
  • MCL
  • MCL
  • MPCL
  • CD368
  • CLEC6
  • CLEC-6
  • CLECSF8
  • Dectin-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.73
virus perturbation
0.72
gene perturbation
0.68
tissue
0.59
microRNA
0.54


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.7   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.7   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
C-type lectin domain family 4 member D
716298
Mouse
MGI:1298389
17474
Rat
RGD:1303339
362432
Cow
C-type lectin domain family 4 member D
VGNC:27431
616646
Species
Name
OMA
EggNOG
Inparanoid
Macaque
C-type lectin domain family 4 member D
Mouse
Rat
Cow
C-type lectin domain family 4 member D
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WXI8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (152)
1 – 10 of 152
CLEC12A
Tbio
Novelty:  0.01478908
Score:  0.97
Data Source:  STRINGDB
MCEMP1
Tdark
Novelty:  0.14180782
Score:  0.946
Data Source:  STRINGDB
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
Score:  0.946
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.943
Data Source:  STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.942
Data Source:  Reactome,STRINGDB
CLEC5A
Tbio
Novelty:  0.01710591
Score:  0.942
Data Source:  STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
Score:  0.935
Data Source:  STRINGDB
ITGAX
Tbio
Novelty:  0.00040471
Score:  0.934
Data Source:  STRINGDB
SLC11A1
Tbio
Family:  Transporter
Novelty:  0.00121416
Score:  0.934
Data Source:  STRINGDB
CD300A
Tbio
Novelty:  0.01745189
Score:  0.931
Data Source:  STRINGDB
Publication Statistics
PubMed Score  23.70

PubMed score by year
PubTator Score  144.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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