CLEC4D
C-type lectin domain family 4 member D
Protein Summary
A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766). Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells (PubMed:14971047). This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family sh ...more
- ENST00000299665
- ENSP00000299665
- ENSG00000166527
- CLECSF8
- MCL
- MCL
- MPCL
- CD368
- CLEC6
- CLEC-6
- CLECSF8
- Dectin-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
phenotype | 0.73 | ||
virus perturbation | 0.72 | ||
gene perturbation | 0.68 | ||
tissue | 0.59 | ||
microRNA | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.7 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 256 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.7 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 256 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (152)
Nearest Tclin Targets
Pathways (6)
Reactome (5)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | Dectin-2 family | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
C-type lectin receptors (CLRs) | ||||
Dectin-2 family | ||||
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (3)
Components (5)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | C-type lectin domain family 4 member D | 716298 | ||||||
Mouse | MGI:1298389 | 17474 | ||||||
Rat | RGD:1303339 | 362432 | ||||||
Cow | C-type lectin domain family 4 member D | VGNC:27431 | 616646 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | C-type lectin domain family 4 member D | |||||
Mouse | ||||||
Rat | ||||||
Cow | C-type lectin domain family 4 member D | |||||
Publication Statistics
PubMed Score 23.70
PubMed score by year
PubTator Score 144.59
PubTator score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (3)
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