CLEC4D
C-type lectin domain family 4 member D
Protein Classes
Protein Summary
A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766). Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells (PubMed:14971047). This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family sh ...more
- ENST00000299665
- ENSP00000299665
- ENSG00000166527
- CLECSF8
- MCL
- MCL
- MPCL
- CD368
- CLEC6
- CLEC-6
- CLECSF8
- Dectin-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
phenotype | 0.73 | ||
virus perturbation | 0.72 | ||
gene perturbation | 0.68 | ||
tissue | 0.59 | ||
microRNA | 0.54 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.7 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 256 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.7 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 256 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | C-type lectin domain family 4 member D | 716298 | ||||||
Mouse | MGI:1298389 | 17474 | ||||||
Rat | RGD:1303339 | 362432 | ||||||
Cow | C-type lectin domain family 4 member D | VGNC:27431 | 616646 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | C-type lectin domain family 4 member D | |||||
Mouse | ||||||
Rat | ||||||
Cow | C-type lectin domain family 4 member D | |||||
Protein Structure (2 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (6)
Reactome (5)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | Dectin-2 family | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
C-type lectin receptors (CLRs) | ||||
Dectin-2 family | ||||
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Gene Ontology Terms (16)
Functions (3)
Components (5)
Processes (8)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (152)
1 – 10 of 152
CLEC12A
Novelty: 0.01478908
Score: 0.97
Data Source: STRINGDB
MCEMP1
Novelty: 0.14180782
Score: 0.946
Data Source: STRINGDB
FPR2
Family: GPCR
Novelty: 0.00228744
Score: 0.946
Data Source: STRINGDB
ITGAM
Novelty: 0.00017521
Score: 0.943
Data Source: STRINGDB
FCER1G
Novelty: 0.00783146
Score: 0.942
Data Source: Reactome,STRINGDB
CLEC5A
Novelty: 0.01710591
Score: 0.942
Data Source: STRINGDB
C3AR1
Family: GPCR
Novelty: 0.00527301
Score: 0.935
Data Source: STRINGDB
ITGAX
Novelty: 0.00040471
Score: 0.934
Data Source: STRINGDB
SLC11A1
Family: Transporter
Novelty: 0.00121416
Score: 0.934
Data Source: STRINGDB
CD300A
Novelty: 0.01745189
Score: 0.931
Data Source: STRINGDB
Publication Statistics
PubMed Score 23.70
PubMed score by year
PubTator Score 144.59
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
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