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Tbio
MUC16
Mucin-16

Protein Summary
Description
Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane d ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397910
  • ENSP00000381008
  • ENSG00000181143

Symbol
  • CA125
  • CA125
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.96
cellular component
0.82
cell type or tissue
0.61
cell line
0.54
protein complex
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.97   (req: < 5)
Gene RIFs: 257   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.97   (req: >= 5)
Gene RIFs: 257   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer antigen 125 measurement
1
1
1
76
1
1
0
1
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer antigen 125 measurement
1
76
0
1
1.4
Pathways (15)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Reactome
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Reactome
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Gene Ontology Terms (9)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (92)
1 – 10 of 92
MUC4
Tbio
Novelty: 0.00193208
Score: 0.986
Data Source: STRINGDB
MUC1
Tbio
Novelty: 0.00024203
Score: 0.979
Data Source: STRINGDB
MUC5AC
Tbio
Novelty: 0.00074159
Score: 0.979
Data Source: STRINGDB
MUC5B
Tbio
Novelty: 0.000832
Score: 0.976
Data Source: STRINGDB
MUC20
Tbio
Novelty: 0.04645313
Score: 0.975
Data Source: STRINGDB
MUC6
Tbio
Novelty: 0.00304872
Score: 0.974
Data Source: STRINGDB
MUC17
Tbio
Novelty: 0.03624836
Score: 0.972
Data Source: STRINGDB
MUC15
Tbio
Novelty: 0.02213624
Score: 0.972
Data Source: STRINGDB
MUC13
Tbio
Novelty: 0.01282861
Score: 0.972
Data Source: STRINGDB
MUC12
Tbio
Novelty: 0.04323645
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  286.97

PubMed score by year
PubTator Score  4189.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer