Tbio MUC16 Mucin-16

Protein Summary

Description

Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q8WXI7
• B5ME49
• Q6ZQW5
• Q96RK2
• MUC-16

Gene Name

• MUC16

Ensembl ID

• ENST00000397910
• ENSP00000381008
• ENSG00000181143

Symbol

• CA125
• CA125

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.96
cellular component	0.82
cell type or tissue	0.61
cell line	0.54
protein complex	0.5

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.97   (req: < 5)

Gene RIFs: 257   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.97   (req: >= 5)

Gene RIFs: 257   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cancer antigen 125 measurement	EFO_0010603	1	1	1		76
asthma	EFO_0000270	1	1	0	1	1.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cancer antigen 125 measurement	EFO_0010603	1		76
asthma	EFO_0000270	0	1	1.4

Reset Zoom  Beta Count   Odds Ratio

Pathways (15)

Reactome (15)

C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 15

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Reactome	Dectin-2 family	29 targets	R-HSA-5621480
Reactome	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Reactome	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636
Reactome	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Name	Explore in Pharos	Explore in Source
C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Dectin-2 family	29 targets	R-HSA-5621480
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Gene Ontology Terms (9)

Components (6)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
extrinsic component of membrane	Inferred from Direct Assay (IDA)	UniProtKB
extracellular exosome	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
vesicle	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
Golgi lumen	Traceable Author Statement (TAS)	Reactome
plasma membrane	Traceable Author Statement (TAS)	Reactome
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (92)

Explore Interacting Targets

1 – 10 of 92

• See Interactions on String-DB

MUC4

Tbio

Novelty: 0.00193208

Score: 0.986

Data Source: STRINGDB

MUC1

Tbio

Novelty: 0.00024203

Score: 0.979

Data Source: STRINGDB

MUC5AC

Tbio

Novelty: 0.00074159

Score: 0.979

Data Source: STRINGDB

MUC5B

Tbio

Novelty: 0.000832

Score: 0.976

Data Source: STRINGDB

MUC20

Tbio

Novelty: 0.04645313

Score: 0.975

Data Source: STRINGDB

MUC6

Tbio

Novelty: 0.00304872

Score: 0.974

Data Source: STRINGDB

MUC17

Tbio

Novelty: 0.03624836

Score: 0.972

Data Source: STRINGDB

MUC15

Tbio

Novelty: 0.02213624

Score: 0.972

Data Source: STRINGDB

MUC13

Tbio

Novelty: 0.01282861

Score: 0.972

Data Source: STRINGDB

MUC12

Tbio

Novelty: 0.04323645

Score: 0.972

Data Source: STRINGDB

Publication Statistics

PubMed Score  286.97

PubMed score by year

Reset Zoom

PubTator Score  4189.28

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

asthma
cancer antigen 125 measurement

MGI Phenotype Find Similar Targets

reproductive system phenotype