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Tbio
SOCS4
Suppressor of cytokine signaling 4

Protein Summary
Description
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339298
  • ENSP00000341327
  • ENSG00000180008
  • ENST00000395472
  • ENSP00000378855
  • ENST00000555846
  • ENSP00000452522

Symbol
  • SOCS7
  • SOCS7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.86
histone modification site profile
0.85
biological process
0.78
virus perturbation
0.76
protein domain
0.73


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.63   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.63   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
suppressor of cytokine signaling 4
696146
Mouse
MGI:1914546
67296
Rat
RGD:1306503
305828
Dog
suppressor of cytokine signaling 4
VGNC:46651
100687271
Horse
suppressor of cytokine signaling 4
VGNC:23438
100050301
Species
Name
OMA
EggNOG
Inparanoid
Macaque
suppressor of cytokine signaling 4
Mouse
Rat
Dog
suppressor of cytokine signaling 4
Horse
suppressor of cytokine signaling 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WXH5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (45)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Reactome
Transcriptional regulation by RUNX1
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Transcriptional regulation by RUNX1
Gene Ontology Terms (5)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-UniPathway
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (55)
1 – 10 of 55
RNF7
Tbio
Novelty: 0.02532658
p_int: 0.999984715
p_ni: 2.2e-8
p_wrong: 0.000015263
Score: 0.565
Data Source: BioPlex,STRINGDB
CUL5
Tbio
Novelty: 0.00792494
p_int: 0.999318009
p_ni: 1e-9
p_wrong: 0.00068199
Score: 0.751
Data Source: BioPlex,STRINGDB
ELOC
Tbio
Novelty: 0.00964847
Score: 0.988
Data Source: STRINGDB
ELOB
Tbio
Novelty: 0.01315739
Score: 0.963
Data Source: STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.92
Data Source: STRINGDB
RUNX1
Tbio
Family: TF
Novelty: 0.0085181
Score: 0.904
Data Source: STRINGDB
CBFB
Tchem
Family: TF
Novelty: 0.04825679
Score: 0.9
Data Source: STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.889
Data Source: STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.861
Data Source: STRINGDB
IRS2
Tbio
Novelty: 0.00164304
Score: 0.843
Data Source: STRINGDB
Publication Statistics
PubMed Score  50.63

PubMed score by year
PubTator Score  11.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer