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Tdark
ASB11
Ankyrin repeat and SOCS box protein 11

Protein Summary
Description
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344384
  • ENSP00000343408
  • ENSG00000165192
  • ENST00000380470
  • ENSP00000369837
  • ENST00000480796
  • ENSP00000417914
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.63
transcription factor
0.52
cell line
0.47
microRNA
0.46
tissue
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.31   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.31   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (340)
ASB6
Tdark
Novelty:  0.32074223
Score:  0.952
Data Source:  STRINGDB
CISH
Tbio
Novelty:  0.00145893
Score:  0.95
Data Source:  STRINGDB
CUL5
Tbio
Novelty:  0.00792494
Score:  0.947
Data Source:  STRINGDB
RNF19B
Tbio
Family:  Enzyme
Novelty:  0.20054824
Score:  0.944
Data Source:  STRINGDB
UBE2D4
Tbio
Novelty:  0.40836104
Score:  0.942
Data Source:  STRINGDB
KLHL41
Tbio
Novelty:  0.03973182
Score:  0.941
Data Source:  STRINGDB
LMO7
Tbio
Novelty:  0.03508141
Score:  0.94
Data Source:  STRINGDB
ASB4
Tbio
Novelty:  0.09903118
Score:  0.94
Data Source:  STRINGDB
ASB2
Tbio
Novelty:  0.02852942
Score:  0.935
Data Source:  STRINGDB
ASB1
Tdark
Novelty:  0.0931554
Score:  0.935
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vascular endothelial growth factor D measurement
1
2
0
1.6
76.7
sex hormone-binding globulin measurement
4
2
4
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vascular endothelial growth factor D measurement
0
1.6
76.7
sex hormone-binding globulin measurement
4
70.4
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1916104
68854
Rat
Dog
ankyrin repeat and SOCS box containing 11
VGNC:38156
612782
Horse
ankyrin repeat and SOCS box containing 11
VGNC:15563
100050799
Cow
ankyrin repeat and SOCS box containing 11
VGNC:26188
511852
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ankyrin repeat and SOCS box containing 11
Horse
ankyrin repeat and SOCS box containing 11
Cow
ankyrin repeat and SOCS box containing 11
Publication Statistics
PubMed Score 1.31
PubMed score by year
PubTator Score 0.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title