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Tbio
SYNE2
Nesprin-2

Protein Summary
Description
Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341472
  • ENSP00000344528
  • ENSG00000054654
  • ENST00000344113
  • ENSP00000341781
  • ENST00000358025
  • ENSP00000350719
  • ENST00000458046
  • ENSP00000391937
  • ENST00000639659
  • ENSP00000492333

Symbol
  • KIAA1011
  • NUA
  • NUA
  • EDMD5
  • KASH2
  • Nesp2
  • TROPH
  • NUANCE
  • SYNE-2
  • Nesprin-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
virus perturbation
0.95
cellular component
0.87
protein domain
0.85
transcription factor
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.47   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.47   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
2
4
95.5
sphingolipid measurement
2
2
2
93.9
metabolite measurement
1
11
28
93.4
sphingomyelin measurement
1
5
6
93.3
4
2
0
1.1
90.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
4
95.5
sphingolipid measurement
2
93.9
metabolite measurement
28
93.4
sphingomyelin measurement
6
93.3
0
1.1
90.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spectrin repeat containing nuclear envelope protein 2
VGNC:10314
746581
Mouse
MGI:2449316
319565
Dog
spectrin repeat containing nuclear envelope protein 2
VGNC:47028
490729
Cow
spectrin repeat containing nuclear envelope protein 2
VGNC:35521
540504
Pig
spectrin repeat containing nuclear envelope protein 2
100524661
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spectrin repeat containing nuclear envelope protein 2
Mouse
Dog
spectrin repeat containing nuclear envelope protein 2
Cow
spectrin repeat containing nuclear envelope protein 2
Pig
spectrin repeat containing nuclear envelope protein 2
Protein Structure (2 Structures, 29 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic synapsis
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic synapsis
Reproduction
Gene Ontology Terms (30)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (112)
1 – 10 of 112
CEP170
Tbio
Novelty:  0.05342931
p_int:  0.999999282
p_ni:  7.12e-7
p_wrong:  7e-9
Score:  0.345
Data Source:  BioPlex,STRINGDB
FRAT2
Tbio
Novelty:  0.14416149
p_int:  0.999997904
p_ni:  0.000002096
Data Source:  BioPlex
CAPN6
Tbio
Novelty:  0.04489237
p_int:  0.999997829
p_ni:  0.000002171
Score:  0.241
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999545813
p_ni:  0.000454186
Score:  0.212
Data Source:  BioPlex,STRINGDB
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.992365402
p_ni:  0.007634596
p_wrong:  2e-9
Score:  0.21
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.970922755
p_ni:  0.029077245
Score:  0.275
Data Source:  BioPlex,STRINGDB
SUN2
Tbio
Novelty:  0.01387591
Score:  0.998
Data Source:  STRINGDB
SUN1
Tbio
Novelty:  0.00931817
Score:  0.993
Data Source:  STRINGDB
LMNB1
Tbio
Novelty:  0.00127348
Score:  0.97
Data Source:  STRINGDB
EMD
Tbio
Novelty:  0.00135202
Score:  0.94
Data Source:  STRINGDB
Publication Statistics
PubMed Score  80.47

PubMed score by year
PubTator Score  43.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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