Tbio SYNE2 Nesprin-2

Protein Summary

Description

Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q8WXH0
• B4DND7
• B4DPR6
• I6XXQ5
• Q540G1
• Q86YP9
• Q8N1S3
• Q8NF49
• Q8TER7
• Q8WWW3
• Q8WWW4
• Q8WWW5
• Q8WXH1
• Q9NU50
• Q9UFQ4
• Q9Y2L4
• Q9Y4R1

Gene Name

• SYNE2

Ensembl ID

• ENST00000341472
• ENSP00000344528
• ENSG00000054654
• ENST00000344113
• ENSP00000341781
• ENST00000358025
• ENSP00000350719
• ENST00000458046
• ENSP00000391937
• ENST00000639659
• ENSP00000492333

Symbol

• KIAA1011
• NUA
• NUA
• EDMD5
• KASH2
• Nesp2
• TROPH
• NUANCE
• SYNE-2
• Nesprin-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.96
virus perturbation	0.95
cellular component	0.87
protein domain	0.85
transcription factor	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.92   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.92   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0