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Tbio
S100Z
Protein S100-Z

Protein Summary
Description
Members of the S100 protein family contain 2 calcium-binding EF-hands and exhibit cell-type specific expression patterns. For additional background information on S100 proteins, see MIM 114085.[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317593
  • ENSP00000320430
  • ENSG00000171643
  • ENST00000513010
  • ENSP00000426768
  • ENST00000613039
  • ENSP00000483535

Symbol
  • Gm625
  • S100-zeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.67
tissue
0.64
tissue sample
0.49
cell line
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.02   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.02   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
S100A1
Tbio
Novelty:  0.00309618
Score:  0.816
Data Source:  STRINGDB
S100A10
Tbio
Novelty:  0.00281525
Score:  0.811
Data Source:  STRINGDB
S100B
Tchem
Novelty:  0.00031007
Score:  0.802
Data Source:  STRINGDB
S100A3
Tbio
Novelty:  0.03024004
Score:  0.791
Data Source:  STRINGDB
S100P
Tbio
Novelty:  0.03293676
Score:  0.777
Data Source:  STRINGDB
S100A13
Tbio
Novelty:  0.0283577
Score:  0.664
Data Source:  STRINGDB
SV2C
Tbio
Novelty:  0.03221681
Score:  0.641
Data Source:  STRINGDB
CRHBP
Tbio
Novelty:  0.00726484
Score:  0.631
Data Source:  STRINGDB
IQGAP2
Tbio
Family:  Enzyme
Novelty:  0.03317992
Score:  0.597
Data Source:  STRINGDB
S100A7L2
Tdark
Novelty:  0.90666307
Score:  0.59
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
47.7
mean platelet volume
1
1
1
40.4
proteinase-activated receptor 1 measurement
1
1
1
32.8
reticulocyte count
1
1
1
12.8
platelet count
1
1
0
6.1
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
47.7
mean platelet volume
1
40.4
proteinase-activated receptor 1 measurement
1
32.8
reticulocyte count
1
12.8
platelet count
0
6.1
5.3
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein Z
VGNC:4154
471509
Mouse
MGI:2685471
268686
Rat
RGD:1562902
294661
Horse
S100 calcium binding protein Z
VGNC:22659
100073276
Cow
S100 calcium binding protein Z
VGNC:34251
528723
Species
Name
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein Z
Mouse
Rat
Horse
S100 calcium binding protein Z
Cow
S100 calcium binding protein Z
Publication Statistics
PubMed Score 8.02
PubMed score by year
PubTator Score 3.39
PubTator score by year
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Related Publications
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PMID
Year
Title