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Tbio
MADD
MAP kinase-activating death domain protein

Protein Summary
Description
Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect. Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311027
  • ENSP00000310933
  • ENSG00000110514
  • ENST00000349238
  • ENSP00000304505
  • ENST00000395336
  • ENSP00000378745
  • ENST00000395344
  • ENSP00000378753
  • ENST00000402192
  • ENSP00000384287
  • ENST00000402799
  • ENSP00000385585
  • ENST00000406482
  • ENSP00000384435
  • ENST00000407859
  • ENSP00000384204

Symbol
  • DENN
  • IG20
  • KIAA0358
  • DENN
  • IG20
  • RAB3GEP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor
0.86
kinase perturbation
0.84
transcription factor binding site profile
0.79
cell line
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.14   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.14   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
4
8
96.3
insulin measurement
1
3
3
90.4
neuroticism measurement
3
1
1
7.6
86.1
fasting blood glucose measurement
4
1
4
82.3
mathematical ability
1
1
1
80.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
8
96.3
insulin measurement
3
90.4
neuroticism measurement
1
7.6
86.1
fasting blood glucose measurement
4
82.3
mathematical ability
1
80.8
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MAP kinase activating death domain
VGNC:6747
451167
Macaque
MAP kinase activating death domain
713613
Mouse
MGI:2444672
228355
Rat
RGD:619922
94193
Dog
MAP kinase activating death domain
VGNC:42917
475982
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MAP kinase activating death domain
Macaque
MAP kinase activating death domain
Mouse
Rat
Dog
MAP kinase activating death domain
Pathways (16)
Death Receptor Signalling (R-HSA-73887)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Regulation of TNFR1 signaling
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Regulation of TNFR1 signaling
Protein-Protein Interactions (110)
1 – 10 of 110
SYT9
Tbio
Novelty: 0.03474091
p_int: 0.999978015
p_ni: 0.000021985
Data Source: BioPlex
SYT12
Tbio
Novelty: 0.03410873
p_int: 0.99841559
p_ni: 0.00158441
Score: 0.238
Data Source: BioPlex,STRINGDB
NXPH2
Tdark
Novelty: 0.65790631
p_int: 0.997157935
p_ni: 0.002842064
p_wrong: 1e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
BBS7
Tbio
Novelty: 0.03611111
p_int: 0.990659914
p_ni: 0.009340065
p_wrong: 2e-8
Score: 0.164
Data Source: BioPlex,STRINGDB
SYT3
Tbio
Novelty: 0.02593006
p_int: 0.971027641
p_ni: 0.028972358
p_wrong: 1e-9
Score: 0.8
Data Source: BioPlex,STRINGDB
SYT6
Tbio
Novelty: 0.03549215
p_int: 0.937450516
p_ni: 0.062549484
Score: 0.822
Data Source: BioPlex,STRINGDB
DOCK5
Tbio
Novelty: 0.03153692
p_int: 0.935002107
p_ni: 0.064997893
Data Source: BioPlex
LCN8
Tbio
Novelty: 0.02098116
p_int: 0.916428041
p_ni: 0.083571959
Data Source: BioPlex
SPCS3
Tbio
Family: Enzyme
Novelty: 0.13677259
p_int: 0.885847799
p_ni: 0.114152201
Data Source: BioPlex
SNX21
Tdark
Novelty: 0.32916633
p_int: 0.878151203
p_ni: 0.121848797
Data Source: BioPlex
Publication Statistics
PubMed Score  68.14

PubMed score by year
PubTator Score  86.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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