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Tbio
ATL1
Atlastin-1

Protein Summary
Description
GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:27619977). May also regulate Golgi biogenesis. May regulate axonal development. The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358385
  • ENSP00000351155
  • ENSG00000198513
  • ENST00000441560
  • ENSP00000413675

Symbol
  • GBP3
  • SPG3A
  • FSP1
  • GBP3
  • SPG3
  • HSN1D
  • SPG3A
  • AD-FSP
  • atlastin1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
transcription factor binding site profile
0.84
cellular component
0.72
transcription factor
0.65
tissue sample
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.44   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.44   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Dupuytren Contracture
1
1
0
1.2
72
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Dupuytren Contracture
0
1.2
72
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
atlastin GTPase 1
VGNC:3476
467452
Macaque
atlastin GTPase 1
706313
Mouse
MGI:1921241
73991
Rat
RGD:1359232
362750
Dog
atlastin GTPase 1
VGNC:38230
480318
Species
Name
OMA
EggNOG
Inparanoid
Chimp
atlastin GTPase 1
Macaque
atlastin GTPase 1
Mouse
Rat
Dog
atlastin GTPase 1
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WXF7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (57)
1 – 10 of 57
SPAST
Tbio
Novelty: 0.00303236
Score: 0.956
Data Source: STRINGDB
REEP1
Tbio
Novelty: 0.02280713
Score: 0.887
Data Source: STRINGDB
RTN4
Tbio
Novelty: 0.00080371
Score: 0.869
Data Source: STRINGDB
RTN1
Tbio
Novelty: 0.01828064
Score: 0.815
Data Source: STRINGDB
RTN2
Tbio
Novelty: 0.05184418
Score: 0.776
Data Source: STRINGDB
REEP5
Tbio
Novelty: 0.00160455
Score: 0.689
Data Source: STRINGDB
SPART
Tbio
Novelty: 0.01524727
Score: 0.688
Data Source: STRINGDB
SPG7
Tbio
Family: Enzyme
Novelty: 0.00463357
Score: 0.683
Data Source: STRINGDB
REEP2
Tdark
Novelty: 0.23897587
Score: 0.678
Data Source: STRINGDB
NIPA1
Tbio
Novelty: 0.02398766
Score: 0.673
Data Source: STRINGDB
Publication Statistics
PubMed Score  144.44

PubMed score by year
PubTator Score  134.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer