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Tdark
CRYGN
Gamma-crystallin N

Protein Summary
Description
This gene encodes a member of the crystallin family of proteins that are localized to the refractive structure of vertebrate eye lenses. The protein encoded by this gene is unique in that it has both beta and gamma crystallin protein motifs. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337323
  • ENSP00000338613
  • ENSG00000127377
  • ENST00000491928
  • ENSP00000420157
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
PubMedID
0.78
cellular component
0.64
tissue
0.54
cell line
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.96   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.96   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (23)
1 – 10 of 23
CKM
Tbio
Family: Kinase
Novelty: 0.00239628
p_int: 0.999509475
p_ni: 0.000395209
p_wrong: 0.000095316
Data Source: BioPlex
ALOX12B
Tbio
Family: Enzyme
Novelty: 0.02778552
p_int: 0.809677073
p_ni: 0.190322926
p_wrong: 1e-9
Data Source: BioPlex
B9D1
Tbio
Novelty: 0.11567839
p_int: 0.77998549
p_ni: 0.000028167
p_wrong: 0.219986343
Data Source: BioPlex
CRYAA2
Tdark
Novelty: 0.01914081
Score: 0.594
Data Source: STRINGDB
CRYAA
Tbio
Novelty: 0.01914081
Score: 0.594
Data Source: STRINGDB
FAM174B
Tdark
Novelty: 0.54823112
Score: 0.584
Data Source: STRINGDB
TSPO2
Tbio
Novelty: 0.17373697
Score: 0.565
Data Source: STRINGDB
BFSP1
Tbio
Novelty: 0.01519136
Score: 0.553
Data Source: STRINGDB
SULT2B1
Tbio
Family: Enzyme
Novelty: 0.02652128
Score: 0.551
Data Source: STRINGDB
GRIFIN
Tdark
Novelty: 0.1208389
Score: 0.542
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.96

PubMed score by year
PubTator Score  2.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer