Tbio STON2 Stonin-2

Protein Classes

PANTHER Classes

Protein / Receptor / Stonin-2

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Stonin-2

Protein Summary

Description

Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• Q8WXE9
• G3V2T7
• Q17R24
• Q59H11
• Q6NT47
• Q96RI7
• Q96RU6

Gene Name

• STON2

Ensembl ID

• ENST00000267540
• ENSP00000267540
• ENSG00000140022
• ENST00000555447
• ENSP00000450857
• ENST00000614646
• ENSP00000477736

Symbol

• STN2
• STNB
• STN2
• STNB
• STNB2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.9
cellular component	0.77
virus perturbation	0.76
cell line	0.66
protein domain	0.58

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.54   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 19   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.54   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 19   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (4)

Reactome (4)

Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Membrane Trafficking	612 targets	R-HSA-199991
Vesicle-mediated transport	725 targets	R-HSA-5653656

Gene Ontology Terms (11)

Components (7)

Processes (4)

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
cytosol	Inferred from Direct Assay (IDA)	HPA
nucleolus	Inferred from Direct Assay (IDA)	HPA
cell junction	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
clathrin-coated vesicle	Inferred from Electronic Annotation (IEA)	Ensembl
membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
neuron projection	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
synaptic vesicle	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (186)

Explore Interacting Targets

1 – 10 of 186

• See Interactions on String-DB

AP2S1

Tbio

Novelty: 0.03619645

p_int: 0.99999997

p_ni: 2.6e-8

p_wrong: 4e-9

Score: 0.965

Data Source: BioPlex,STRINGDB

AP2M1

Tbio

Novelty: 0.01240983

p_int: 0.999999867

p_ni: 1.33e-7

Score: 0.966

Data Source: BioPlex,STRINGDB

EPS15L1

Tbio

Novelty: 0.08281964

p_int: 0.999999865

p_ni: 1.35e-7

Score: 0.983

Data Source: BioPlex,STRINGDB

LSR

Tbio

Novelty: 0.0032892

p_int: 0.999990119

p_ni: 0.000009878

p_wrong: 3e-9

Score: 0.157

Data Source: BioPlex,STRINGDB

CLINT1

Tbio

Novelty: 0.00532807

p_int: 0.999901492

p_ni: 0.000098369

p_wrong: 1.39e-7

Score: 0.718

Data Source: BioPlex,STRINGDB

SLC25A41

Tdark

Family: Transporter

Novelty: 2.02597403

p_int: 0.998111089

p_ni: 0.000322264

p_wrong: 0.001566647

Score: 0.528

Data Source: BioPlex,STRINGDB

CCDC32

Tdark

Novelty: 4

p_int: 0.98878603

p_ni: 0.001657952

p_wrong: 0.009556018

Data Source: BioPlex

EPS15

Tbio

Novelty: 0.00518368

Score: 0.995

Data Source: STRINGDB

SYT1

Tbio

Novelty: 0.00202951

Score: 0.992

Data Source: Reactome,STRINGDB

SYT2

Tbio

Novelty: 0.01076581

Score: 0.983

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  31.54

PubMed score by year

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PubTator Score  16.78

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MTTLDHVIATHQSEWVSFNEEPPFPAHSQGGTEEHLPGLSSSPDQSESSSGENHVVDGGSQDHSHSEQDD

1-70

SSEKMGLISEAASPPGSPEQPPPDLASAISNWVQFEDDTPWASTSPPHQETAETALPLTMPCWTCPSFDS

70-140

LGRCPLTSESSWTTHSEDTSSPSFGCSYTDLQLINAEEQTSGQASGADSTDNSSSLQEDEEVEMEAISWQ

140-210

ASSPAMNGHPAPPVTSARFPSWVTFDDNEVSCPLPPVTSPLKPNTPPSASVIPDVPYNSMGSFKKRDRPK

210-280

STLMNFSKVQKLDISSLNRTPSVTEASPWRATNPFLNETLQDVQPSPINPFSAFFEEQERRSQNSSISST

280-350

TGKSQRDSLIVIYQDAISFDDSSKTQSHSDAVEKLKQLQIDDPDHFGSATLPDDDPVAWIELDAHPPGSA

350-420

RSQPRDGWPMMLRIPEKKNIMSSRHWGPIFVKLTDTGYLQLYYEQGLEKPFREFKLEICHEISEPRLQNY

420-490

DENGRIHSLRIDRVTYKEKKKYQPKPAVAHTAEREQVIKLGTTNYDDFLSFIHAVQDRLMDLPVLSMDLS

490-560

TVGLNYLEEEITVDVRDEFSGIVSKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILVKGNEIVLRQD

560-630

IMPTTTTKWIKLHECRFHGCVDEDVFHNSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTATSVNGAE

630-700

VEVQSWLRMSTGFSANRDPLTQVPCENVMIRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSTSVSG

700-770

SEPVMRVTLGTAKYEHAFNSIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTT

770-840

SASKASVRSISVEDKTDVRKWVNYSAHYSYQVALGSIWLMLPTPFVHPTTLPLLFLLAMLTMFAW

840-905

MTTLDHVIATHQSEWVSFNEEPPFPAHSQGGTEEHLPGLSSSPDQSESSSGENHVVDGGSQDHSHSEQDDSSEKMGLISEAASPPGSPEQPPPDLASAISNWVQFEDDTPWASTSPPHQETAETALPLTMPCWTCPSFDSLGRCPLTSESSWTTHSEDTSSPSFGCSYTDLQLINAEEQTSGQASGADSTDNSSSLQEDEEVEMEAISWQASSPAMNGHPAPPVTSARFPSWVTFDDNEVSCPLPPVTSPLKPNTPPSASVIPDVPYNSMGSFKKRDRPKSTLMNFSKVQKLDISSLNRTPSVTEASPWRATNPFLNETLQDVQPSPINPFSAFFEEQERRSQNSSISSTTGKSQRDSLIVIYQDAISFDDSSKTQSHSDAVEKLKQLQIDDPDHFGSATLPDDDPVAWIELDAHPPGSARSQPRDGWPMMLRIPEKKNIMSSRHWGPIFVKLTDTGYLQLYYEQGLEKPFREFKLEICHEISEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHTAEREQVIKLGTTNYDDFLSFIHAVQDRLMDLPVLSMDLSTVGLNYLEEEITVDVRDEFSGIVSKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILVKGNEIVLRQDIMPTTTTKWIKLHECRFHGCVDEDVFHNSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTATSVNGAEVEVQSWLRMSTGFSANRDPLTQVPCENVMIRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSTSVSGSEPVMRVTLGTAKYEHAFNSIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTTSASKASVRSISVEDKTDVRKWVNYSAHYSYQVALGSIWLMLPTPFVHPTTLPLLFLLAMLTMFAW

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Uniprot Keyword

3D-structure
Alternative splicing
Cell junction
Complete proteome
Cytoplasm
Endocytosis
Membrane
Phosphoprotein
Polymorphism
Reference proteome