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Tdark
CASKIN2
Caskin-2

Protein Summary
Description
This gene encodes a large protein that contains six ankyrin repeats, as well as a Src homology 3 (SH3) domain and two sterile alpha motif (SAM) domains, which may be involved in protein-protein interactions. The C-terminal portion of this protein is proline-rich and contains a conserved region. A related protein interacts with calcium/calmodulin-dependent serine protein kinase (CASK). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321617
  • ENSP00000325355
  • ENSG00000177303
  • ENST00000433559
  • ENSP00000406963

Symbol
  • KIAA1139
  • ANKS5B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor
0.86
transcription factor binding site profile
0.79
cell type or tissue
0.76
cell line
0.72


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.4   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.4   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CASK interacting protein 2
VGNC:9137
737225
Macaque
CASK interacting protein 2
702477
Mouse
MGI:2157062
140721
Rat
RGD:1309738
303678
Dog
CASK interacting protein 2
VGNC:38731
483314
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CASK interacting protein 2
Macaque
CASK interacting protein 2
Mouse
Rat
Dog
CASK interacting protein 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WXE0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (38)
1 – 10 of 38
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.999999993
p_ni: 1e-9
p_wrong: 7e-9
Score: 0.591
Data Source: BioPlex,STRINGDB
ABI2
Tbio
Novelty: 0.02324355
p_int: 0.999999889
p_ni: 1e-7
p_wrong: 1.1e-8
Score: 0.72
Data Source: BioPlex,STRINGDB
NCK1
Tbio
Novelty: 0.00352084
p_int: 0.999993167
p_ni: 0.000002931
p_wrong: 0.000003902
Score: 0.202
Data Source: BioPlex,STRINGDB
P4HA3
Tbio
Family: Enzyme
Novelty: 0.03832564
p_int: 0.999826725
p_ni: 0.000030101
p_wrong: 0.000143174
Score: 0.285
Data Source: BioPlex,STRINGDB
TMEM161A
Tdark
Novelty: 0.74152096
Score: 0.777
Data Source: STRINGDB
SLC25A42
Tbio
Family: Transporter
Novelty: 0.15737382
Score: 0.762
Data Source: STRINGDB
TMEM94
Tdark
Novelty: 0.39746809
Score: 0.76
Data Source: STRINGDB
APBA1
Tbio
Novelty: 0.01126648
Score: 0.654
Data Source: STRINGDB
FBXO24
Tdark
Novelty: 0.70806401
Score: 0.642
Data Source: STRINGDB
NRXN1
Tbio
Novelty: 0.00454659
Score: 0.633
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.40

PubMed score by year
PubTator Score  2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer