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Tbio
GEMIN6
Gem-associated protein 6

Protein Summary
Description
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Oth ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281950
  • ENSP00000281950
  • ENSG00000152147
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor perturbation
0.84
virus perturbation
0.83
interacting protein
0.8
tissue sample
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.66   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.66   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gem nuclear organelle associated protein 6
VGNC:2923
459168
Mouse
MGI:1914492
67242
Rat
RGD:1311168
362688
Dog
gem nuclear organelle associated protein 6
VGNC:41176
475732
Horse
gem nuclear organelle associated protein 6
VGNC:18305
100053991
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gem nuclear organelle associated protein 6
Mouse
Rat
Dog
gem nuclear organelle associated protein 6
Horse
gem nuclear organelle associated protein 6
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WXD5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
snRNP Assembly
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of non-coding RNA
snRNP Assembly
Gene Ontology Terms (11)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (87)
1 – 10 of 87
GEMIN8
Tbio
Novelty: 0.19515325
p_int: 1
Score: 0.997
Data Source: BioPlex,STRINGDB
GEMIN7
Tbio
Novelty: 0.04835353
p_int: 0.999989011
p_ni: 0.000010989
Score: 0.999
Data Source: BioPlex,STRINGDB
STRAP
Tbio
Family: Enzyme
Novelty: 0.0336013
p_int: 0.999948692
p_ni: 0.000051308
Score: 0.995
Data Source: BioPlex,STRINGDB
DDX20
Tbio
Family: Enzyme
Novelty: 0.01854078
p_int: 0.999871151
p_ni: 0.000128849
Score: 0.995
Data Source: BioPlex,STRINGDB
SNRNP70
Tbio
Novelty: 0.00116631
p_int: 0.999114605
p_ni: 0.000885395
Score: 0.544
Data Source: BioPlex,STRINGDB
GEMIN2
Tbio
Novelty: 0.02072868
p_int: 0.998558095
p_ni: 0.001441905
Score: 0.998
Data Source: BioPlex,STRINGDB
SNRPF
Tdark
Novelty: 0.17624854
p_int: 0.996564784
p_ni: 0.003435216
Score: 0.96
Data Source: BioPlex,STRINGDB
GEMIN4
Tbio
Novelty: 0.03731756
p_int: 0.989759863
p_ni: 0.010240137
Score: 0.998
Data Source: BioPlex,STRINGDB
NCKIPSD
Tbio
Novelty: 0.07453111
p_int: 0.971679334
p_ni: 0.028320654
p_wrong: 1.2e-8
Score: 0.309
Data Source: BioPlex,STRINGDB
SNRPGP15
Tdark
p_int: 0.966031782
p_ni: 0.033968218
Data Source: BioPlex
Publication Statistics
PubMed Score  44.66

PubMed score by year
PubTator Score  15.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer