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Tbio
SCG3
Secretogranin-3

Protein Summary
Description
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220478
  • ENSP00000220478
  • ENSG00000104112
  • ENST00000542355
  • ENSP00000445205

Symbol
  • SGIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.84
PubMedID
0.65
disease perturbation
0.62
cellular component
0.61
tissue sample
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.71   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.71   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
4
3
6.1
63.9
mean reticulocyte volume
1
1
1
44.2
body height
1
1
1
40.7
cognitive function measurement
3
2
3
34.8
triglyceride measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
6.1
63.9
mean reticulocyte volume
1
44.2
body height
1
40.7
cognitive function measurement
3
34.8
triglyceride measurement
1
33.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secretogranin III
VGNC:10260
453437
Macaque
secretogranin III
694089
Mouse
MGI:103032
20255
Rat
RGD:621209
116635
Dog
secretogranin III
VGNC:45906
478307
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secretogranin III
Macaque
secretogranin III
Mouse
Rat
Dog
secretogranin III
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WXD2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Metabolism of proteins
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Hemostasis
Metabolism of proteins
Platelet activation, signaling and aggregation
Platelet degranulation
Post-translational protein modification
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (142)
1 – 10 of 142
IRGQ
Tdark
Family:  Enzyme
Novelty:  0.9065415
p_int:  0.969984956
p_ni:  0.029989889
p_wrong:  0.000025155
Score:  0.309
Data Source:  BioPlex,STRINGDB
MRE11
Tbio
Novelty:  0.01038348
p_int:  0.882548159
p_ni:  0.117451841
Score:  0.282
Data Source:  BioPlex,STRINGDB
CTH
Tchem
Family:  Enzyme
Novelty:  0.0017155
p_int:  0.789244424
p_ni:  0.210755576
Score:  0.188
Data Source:  BioPlex,STRINGDB
TPM2
Tbio
Novelty:  0.00406572
p_int:  0.787771668
p_ni:  0.212228266
p_wrong:  6.6e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
SCG2
Tbio
Novelty:  0.00389492
Score:  0.987
Data Source:  STRINGDB
CHGA
Tbio
Novelty:  0.00033267
Score:  0.979
Data Source:  STRINGDB
CHGB
Tbio
Novelty:  0.00484507
Score:  0.979
Data Source:  STRINGDB
VGF
Tbio
Novelty:  0.00521876
Score:  0.973
Data Source:  STRINGDB
PENK
Tbio
Novelty:  0.00074167
Score:  0.938
Data Source:  STRINGDB
CST3
Tbio
Novelty:  0.00021856
Score:  0.926
Data Source:  STRINGDB
Publication Statistics
PubMed Score  57.71

PubMed score by year
PubTator Score  28.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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