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Tbio
RXFP2
Relaxin receptor 2

Protein Summary
Description
Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3). This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298386
  • ENSP00000298386
  • ENSG00000133105
  • ENST00000380314
  • ENSP00000369670

Symbol
  • GPR106
  • GREAT
  • LGR8
  • LGR8
  • GREAT
  • GPR106
  • INSL3R
  • LGR8.1
  • RXFPR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
ligand (protein)
0.85
biological process
0.57
cell line
0.56
tissue
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.43   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.43   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (27)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (163)
1 – 10 of 163
INSL3
Tbio
Novelty: 0.00467497
Score: 0.997
Data Source: Reactome,STRINGDB
RLN3
Tbio
Novelty: 0.01243441
Score: 0.982
Data Source: STRINGDB
RLN2
Tbio
Novelty: 0.00846462
Score: 0.98
Data Source: Reactome,STRINGDB
RXFP4
Tbio
Family: GPCR
Novelty: 0.058923
Score: 0.969
Data Source: STRINGDB
RXFP3
Tchem
Family: GPCR
Novelty: 0.02001419
Score: 0.969
Data Source: STRINGDB
RLN1
Tbio
Novelty: 0.05712331
Score: 0.952
Data Source: STRINGDB
LHCGR
Tclin
Family: GPCR
Novelty: 0.00288857
Score: 0.923
Data Source: STRINGDB
TSHR
Tclin
Family: GPCR
Novelty: 0.0008779
Score: 0.922
Data Source: STRINGDB
FSHR
Tclin
Family: GPCR
Novelty: 0.00142021
Score: 0.921
Data Source: STRINGDB
CGA
Tbio
Novelty: 0.00200677
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  85.43

PubMed score by year
PubTator Score  88.77

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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