You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RXFP2
Relaxin receptor 2

Protein Summary
Description
Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3). This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298386
  • ENSP00000298386
  • ENSG00000133105
  • ENST00000380314
  • ENSP00000369670

Symbol
  • GPR106
  • GREAT
  • LGR8
  • LGR8
  • GREAT
  • GPR106
  • INSL3R
  • LGR8.1
  • RXFPR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
ligand (protein)
0.85
biological process
0.57
cell line
0.56
tissue
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.17   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.17   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
45
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
45
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
relaxin family peptide receptor 2
VGNC:13136
467256
Macaque
relaxin/insulin like family peptide receptor 2
721969
Mouse
MGI:2153463
140498
Rat
RGD:1309449
363866
Dog
relaxin/insulin like family peptide receptor 2
450220
Species
Name
OMA
EggNOG
Inparanoid
Chimp
relaxin family peptide receptor 2
Macaque
relaxin/insulin like family peptide receptor 2
Mouse
Rat
Dog
relaxin/insulin like family peptide receptor 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WXD0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (163)
1 – 10 of 163
INSL3
Tbio
Novelty: 0.00374656
Score: 0.997
Data Source: Reactome,STRINGDB
RLN3
Tbio
Novelty: 0.0107593
Score: 0.982
Data Source: STRINGDB
RLN2
Tbio
Novelty: 0.00743118
Score: 0.98
Data Source: Reactome,STRINGDB
RXFP4
Tbio
Family: GPCR
Novelty: 0.05054041
Score: 0.969
Data Source: STRINGDB
RXFP3
Tchem
Family: GPCR
Novelty: 0.01844783
Score: 0.969
Data Source: STRINGDB
RLN1
Tbio
Novelty: 0.03992636
Score: 0.952
Data Source: STRINGDB
LHCGR
Tclin
Family: GPCR
Novelty: 0.00169974
Score: 0.923
Data Source: STRINGDB
TSHR
Tclin
Family: GPCR
Novelty: 0.00074972
Score: 0.922
Data Source: STRINGDB
FSHR
Tclin
Family: GPCR
Novelty: 0.00123929
Score: 0.921
Data Source: STRINGDB
CGA
Tbio
Novelty: 0.00394017
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  108.17

PubMed score by year
PubTator Score  88.77

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: