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Tbio
COPS9
COP9 signalosome complex subunit 9

Protein Summary
Description
Isoform 1: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation. Isoform 2: Negatively regulates neddylation of proteins, including ribosoaml protein RPL11.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307266
  • ENSP00000304147
  • ENSG00000172428
  • ENST00000607357
  • ENSP00000475979

Symbol
  • MYEOV2
  • CSNAP
  • MYEOV2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.06   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 22   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.06   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 22   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (54)
1 – 10 of 54
COPS3
Tbio
Novelty: 0.04664225
p_int: 0.999891828
p_ni: 0.000108172
Score: 0.967
Data Source: BioPlex,STRINGDB
COPS6
Tbio
Novelty: 0.02653008
Score: 0.962
Data Source: STRINGDB
COPS8
Tbio
Novelty: 0.0408885
Score: 0.961
Data Source: STRINGDB
COPS2
Tbio
Novelty: 0.03509351
Score: 0.958
Data Source: STRINGDB
COPS5
Tbio
Novelty: 0.00406225
Score: 0.952
Data Source: STRINGDB
GPS1
Tbio
Novelty: 0.01433636
Score: 0.929
Data Source: STRINGDB
COPS4
Tbio
Novelty: 0.04672417
Score: 0.923
Data Source: STRINGDB
COPS7A
Tbio
Novelty: 0.02159233
Score: 0.91
Data Source: STRINGDB
COPS7B
Tbio
Novelty: 0.63421506
Score: 0.9
Data Source: STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.06

PubMed score by year
PubTator Score  1.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer