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Tbio
PYDC1
Pyrin domain-containing protein 1

Protein Summary
Description
Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302964
  • ENSP00000304336
  • ENSG00000169900

Symbol
  • ASC2
  • ASCI
  • POP1
  • PYC1
  • ASC2
  • POP1
  • PYC1
  • cPOP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.67
cell line
0.46
tissue sample
0.43
hub protein
0.39
cell type or tissue
0.36


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 592.65   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 592.65   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (49)
1 – 10 of 49
F2RL2
Tbio
Family: GPCR
Novelty: 0.2305357
Score: 0.905
Data Source: STRINGDB
PYCARD
Tbio
Novelty: 0.00719985
Score: 0.86
Data Source: STRINGDB
IKBKG
Tbio
Family: Kinase
Novelty: 0.0006149
Score: 0.746
Data Source: STRINGDB
F2R
Tclin
Family: GPCR
Novelty: 0.00080964
Score: 0.741
Data Source: STRINGDB
IKBKB
Tchem
Family: Kinase
Novelty: 0.00090202
Score: 0.735
Data Source: STRINGDB
CHUK
Tchem
Family: Kinase
Novelty: 0.00151532
Score: 0.726
Data Source: STRINGDB
ERC1
Tbio
Novelty: 0.01251
Score: 0.72
Data Source: STRINGDB
TRIM40
Tbio
Novelty: 0.26950973
Score: 0.72
Data Source: STRINGDB
ADCY10
Tchem
Family: Enzyme
Novelty: 0.00037654
Score: 0.691
Data Source: STRINGDB
CBSL
Tdark
Novelty: 0.00062189
Score: 0.67
Data Source: STRINGDB
Publication Statistics
PubMed Score  592.65

PubMed score by year
PubTator Score  26.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer