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Tbio
PYDC1
Pyrin domain-containing protein 1

Protein Summary
Description
Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302964
  • ENSP00000304336
  • ENSG00000169900

Symbol
  • ASC2
  • ASCI
  • POP1
  • PYC1
  • ASC2
  • POP1
  • PYC1
  • cPOP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.67
cell line
0.46
tissue sample
0.43
hub protein
0.39
cell type or tissue
0.36


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 783.87   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 783.87   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
F2RL2
Tbio
Family:  GPCR
Novelty:  0.2305357
Score:  0.905
Data Source:  STRINGDB
PYCARD
Tbio
Novelty:  0.00719985
Score:  0.86
Data Source:  STRINGDB
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
Score:  0.746
Data Source:  STRINGDB
F2R
Tclin
Family:  GPCR
Novelty:  0.00080964
Score:  0.741
Data Source:  STRINGDB
IKBKB
Tchem
Family:  Kinase
Novelty:  0.00090202
Score:  0.735
Data Source:  STRINGDB
CHUK
Tchem
Family:  Kinase
Novelty:  0.00151532
Score:  0.726
Data Source:  STRINGDB
ERC1
Tbio
Novelty:  0.01251
Score:  0.72
Data Source:  STRINGDB
TRIM40
Tbio
Novelty:  0.26950973
Score:  0.72
Data Source:  STRINGDB
ADCY10
Tchem
Family:  Enzyme
Novelty:  0.00037654
Score:  0.691
Data Source:  STRINGDB
CBSL
Tdark
Novelty:  0.00062189
Score:  0.67
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
12
6
0
1.7
99.6
IGF-1 measurement
1
4
4
77.1
body mass index
4
1
5
74.6
1
1
0
1.3
64.4
serum non-albumin protein measurement
1
2
2
56.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
99.6
IGF-1 measurement
4
77.1
body mass index
5
74.6
0
1.3
64.4
serum non-albumin protein measurement
2
56.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyrin domain containing 1
VGNC:9099
742490
Macaque
pyrin domain containing 1
100426067
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyrin domain containing 1
Macaque
pyrin domain containing 1
Publication Statistics
PubMed Score 783.87
PubMed score by year
PubTator Score 26.70
PubTator score by year
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Related Publications
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PMID
Year
Title