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Tdark
ZNF606
Zinc finger protein 606

Protein Summary
Description
May act as a transcriptional repressor. This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) domain at its N-terminus, followed by contiguous C2H2 zinc finger motifs. The encoded protein is a nuclear protein that can act as a transcriptional repressor of growth factor-mediated signaling pathways in a reporter gene assay. This protein has been shown to interact with the SRY-box 9 gene product, and suppresses its transcriptional activity by inhibiting its DNA binding activity. Reduced expression of this gene promotes chondrocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341164
  • ENSP00000343617
  • ENSG00000166704

Symbol
  • KIAA1852
  • ZNF328
  • ZNF328
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.63
disease perturbation
0.62
small molecule perturbation
0.6
virus perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.36   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.36   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
TRIM28
Tbio
Family:  Epigenetic
Novelty:  0.00778381
Score:  0.909
Data Source:  STRINGDB
THOC7
Tbio
Novelty:  0.16971494
Score:  0.82
Data Source:  STRINGDB
THOC5
Tbio
Novelty:  0.04618391
Score:  0.82
Data Source:  STRINGDB
C3orf20
Tdark
Novelty:  3.5419952
Score:  0.643
Data Source:  STRINGDB
ELFN2
Tdark
Family:  Enzyme
Novelty:  0.40013413
Score:  0.559
Data Source:  STRINGDB
C5orf47
Tdark
Novelty:  0.71712425
Score:  0.559
Data Source:  STRINGDB
OR10S1
Tdark
Family:  oGPCR
Novelty:  2.23425255
Score:  0.556
Data Source:  STRINGDB
C2CD4C
Tdark
Novelty:  0.74998413
Score:  0.553
Data Source:  STRINGDB
PUM3
Tbio
Novelty:  0.02344206
Score:  0.536
Data Source:  STRINGDB
PHACTR2
Tbio
Family:  Enzyme
Novelty:  0.25056698
Score:  0.536
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
kidney cancer
1
1
0
2.5
35
sex hormone-binding globulin measurement
2
1
2
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
kidney cancer
0
2.5
35
sex hormone-binding globulin measurement
2
31.4
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 606
VGNC:11502
469047
Mouse
MGI:1914620
67370
Rat
RGD:1309810
292610
Dog
zinc finger protein 606
VGNC:48773
484238
Horse
zinc finger protein 606
VGNC:25354
100063489
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 606
Mouse
Rat
Dog
zinc finger protein 606
Horse
zinc finger protein 606
Publication Statistics
PubMed Score 2.36
PubMed score by year
PubTator Score 1.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title