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Tbio
METTL21A
Protein N-lysine methyltransferase METTL21A

Protein Summary
Description
Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000406927
  • ENSP00000385481
  • ENSG00000144401
  • ENST00000411432
  • ENSP00000415115
  • ENST00000425132
  • ENSP00000400730
  • ENST00000426075
  • ENSP00000403317
  • ENST00000442521
  • ENSP00000392062
  • ENST00000448007
  • ENSP00000407622
  • ENST00000458426
  • ENSP00000389684

Symbol
  • FAM119A
  • HCA557B
  • FAM119A
  • HCA557b
  • HSPA-KMT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
histone modification site profile
0.84
transcription factor binding site profile
0.83
transcription factor perturbation
0.68
transcription factor
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.64   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.64   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methyltransferase like 21A
VGNC:2012
459902
Macaque
methyltransferase like 21A
710435
Mouse
MGI:1914349
67099
Rat
RGD:7651604
102553119
Dog
methyltransferase like 21A [Source:HGNC Symbol;Acc:HGNC:30476]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methyltransferase like 21A
Macaque
methyltransferase like 21A
Mouse
Rat
Dog
methyltransferase like 21A [Source:HGNC Symbol;Acc:HGNC:30476]
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein methylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Protein methylation
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (51)
1 – 10 of 51
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.999980016
p_ni: 0.000019984
Score: 0.956
Data Source: BioPlex,Reactome,STRINGDB
HSPBP1
Tbio
Novelty: 0.01176285
p_int: 0.999146449
p_ni: 0.000853551
Score: 0.534
Data Source: BioPlex,STRINGDB
BAG3
Tbio
Novelty: 0.0042967
p_int: 0.919476875
p_ni: 0.080523125
Score: 0.237
Data Source: BioPlex,STRINGDB
HSPA4
Tbio
Novelty: 0.00009122
p_int: 0.843869876
p_ni: 0.156130124
Score: 0.699
Data Source: BioPlex,STRINGDB
METTL18
Tdark
Family: Enzyme
Novelty: 0.3377377
Score: 0.885
Data Source: STRINGDB
ETFBKMT
Tbio
Family: Enzyme
Novelty: 0.33247149
Score: 0.86
Data Source: STRINGDB
EEF1AKMT1
Tdark
Family: Enzyme
Novelty: 0.22249584
Score: 0.821
Data Source: STRINGDB
EEF2KMT
Tdark
Family: Enzyme
Novelty: 0.33892681
Score: 0.818
Data Source: STRINGDB
CAMKMT
Tbio
Family: Enzyme
Novelty: 0.00382649
Score: 0.786
Data Source: STRINGDB
METTL22
Tdark
Family: Enzyme
Novelty: 0.83516873
Score: 0.783
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.64

PubMed score by year
PubTator Score  3.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer