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Tbio
SREK1
Splicing regulatory glutamine/lysine-rich protein 1

Protein Summary
Description
Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334121
  • ENSP00000334538
  • ENSG00000153914
  • ENST00000380918
  • ENSP00000370305

Symbol
  • SFRS12
  • SRRP86
  • SFRS12
  • SRrp86
  • SRrp508
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
kinase perturbation
0.97
microRNA
0.75
transcription factor binding site profile
0.73
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.76   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.76   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (112)
1 – 10 of 112
PUF60
Tbio
Novelty: 0.0330882
p_int: 0.999999966
p_ni: 3.4e-8
Score: 0.928
Data Source: BioPlex,STRINGDB
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00134844
p_int: 0.99999981
p_ni: 1.9e-7
Score: 0.61
Data Source: BioPlex,STRINGDB
ZRANB2
Tbio
Novelty: 0.02084407
p_int: 0.999307745
p_ni: 0.000692255
Score: 0.727
Data Source: BioPlex,STRINGDB
SPATA1
Tdark
p_int: 0.998033034
p_ni: 0.001966966
Data Source: BioPlex
SRSF8
Tdark
Novelty: 0.32258065
p_int: 0.996939242
p_ni: 0.0030594
p_wrong: 0.000001358
Score: 0.777
Data Source: BioPlex,STRINGDB
PNN
Tbio
Novelty: 0.00945912
p_int: 0.982389814
p_ni: 0.017610186
Score: 0.756
Data Source: BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty: 0.01211318
p_int: 0.977432777
p_ni: 0.022567219
p_wrong: 4e-9
Data Source: BioPlex
CDX1
Tbio
Family: TF
Novelty: 0.00456771
p_int: 0.972777626
p_ni: 0.026997597
p_wrong: 0.000224777
Data Source: BioPlex
RPL37A
Tbio
Novelty: 0.03125092
p_int: 0.956901221
p_ni: 0.042779538
p_wrong: 0.000319241
Score: 0.156
Data Source: BioPlex,STRINGDB
H1FNT
Tdark
Novelty: 0.07619048
p_int: 0.956219414
p_ni: 0.043557377
p_wrong: 0.000223209
Data Source: BioPlex
Publication Statistics
PubMed Score  4.76

PubMed score by year
PubTator Score  5.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer