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Tchem
HTR3C
5-hydroxytryptamine receptor 3C

Protein Classes
Protein Summary
Description
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318351
  • ENSP00000322617
  • ENSG00000178084
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
protein domain
0.73
cell line
0.53
tissue sample
0.42
phenotype
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.01   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.01   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
4.2
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 3C
VGNC:11412
471021
Macaque
5-hydroxytryptamine receptor 3C
706232
Xenopus
5-hydroxytryptamine (serotonin) receptor 3C, ionotropic [Source:Xenbase;Acc:XB-GENE-6037504]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 3C
Macaque
5-hydroxytryptamine receptor 3C
Xenopus
5-hydroxytryptamine (serotonin) receptor 3C, ionotropic [Source:Xenbase;Acc:XB-GENE-6037504]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WXA8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Protein-Protein Interactions (51)
1 – 10 of 51
ABHD16A
Tchem
Family: Enzyme
Novelty: 0.04797219
p_int: 0.999981188
p_ni: 0.000013957
p_wrong: 0.000004855
Score: 0.196
Data Source: BioPlex,STRINGDB
UGT3A2
Tbio
Family: Enzyme
Novelty: 0.35904542
p_int: 0.999883699
p_ni: 0.000090466
p_wrong: 0.000025835
Data Source: BioPlex
SEC11C
Tdark
Family: Enzyme
Novelty: 0.19577003
p_int: 0.999843318
p_ni: 0.000153359
p_wrong: 0.000003323
Score: 0.205
Data Source: BioPlex,STRINGDB
ARHGAP8
Tbio
Family: Enzyme
Novelty: 0.22016818
p_int: 0.999829101
p_ni: 1e-9
p_wrong: 0.000170898
Data Source: BioPlex
TPST2
Tbio
Family: Enzyme
Novelty: 0.02551048
p_int: 0.99963561
p_ni: 0.000364389
p_wrong: 1e-9
Data Source: BioPlex
TUSC3
Tbio
Novelty: 0.01388722
p_int: 0.999297329
p_ni: 0.000702671
Data Source: BioPlex
TMEM186
Tdark
Novelty: 0.59951294
p_int: 0.998720053
p_ni: 0.001279946
Data Source: BioPlex
TMTC3
Tdark
Novelty: 0.17411457
p_int: 0.998493784
p_ni: 0.001506216
Score: 0.498
Data Source: BioPlex,STRINGDB
SPPL2B
Tbio
Family: Enzyme
Novelty: 0.0274774
p_int: 0.99711265
p_ni: 0.00288735
Data Source: BioPlex
TMEM104
Tdark
p_int: 0.99577699
p_ni: 0.003374161
p_wrong: 0.000848849
Score: 0.188
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  7.01

PubMed score by year
PubTator Score  8.17

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer