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Tbio
RUFY2
RUN and FYVE domain-containing protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388768
  • ENSP00000373420
  • ENSG00000204130
  • ENST00000399200
  • ENSP00000382151
  • ENST00000454950
  • ENSP00000404986
  • ENST00000602465
  • ENSP00000473462

Symbol
  • KIAA1537
  • RABIP4R
  • RABIP4R
  • ZFYVE13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.83
transcription factor perturbation
0.8
histone modification site profile
0.76
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.47   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.47   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
4
5
6
98.8
optic disc area measurement
1
1
2
86.4
HbA1c measurement
1
2
2
78.7
optic cup area measurement
2
2
3
54.3
BMI-adjusted hip circumference
1
3
3
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
6
98.8
optic disc area measurement
2
86.4
HbA1c measurement
2
78.7
optic cup area measurement
3
54.3
BMI-adjusted hip circumference
3
45.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RUN and FYVE domain containing 2
VGNC:12488
466094
Macaque
RUN and FYVE domain containing 2
694919
Mouse
MGI:1917682
70432
Dog
RUN and FYVE domain containing 2
VGNC:45804
479228
Horse
RUN and FYVE domain containing 2
VGNC:22625
100063098
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RUN and FYVE domain containing 2
Macaque
RUN and FYVE domain containing 2
Mouse
Dog
RUN and FYVE domain containing 2
Horse
RUN and FYVE domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WXA3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (37)
1 – 10 of 37
RUFY1
Tbio
Novelty:  0.16796947
p_int:  1
Score:  0.815
Data Source:  BioPlex,STRINGDB
PMF1
Tbio
Novelty:  0.05319446
p_int:  0.999999604
p_ni:  3.07e-7
p_wrong:  8.9e-8
Data Source:  BioPlex
CEP170
Tbio
Novelty:  0.05342931
p_int:  0.999997858
p_ni:  0.000002141
p_wrong:  2e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999985571
p_ni:  0.000014421
p_wrong:  8e-9
Data Source:  BioPlex
LAGE3
Tdark
Novelty:  0.02099961
p_int:  0.999600391
p_ni:  0.000399362
p_wrong:  2.47e-7
Data Source:  BioPlex
TPM1
Tbio
Novelty:  0.00261206
p_int:  0.998963136
p_ni:  0.001036864
Score:  0.213
Data Source:  BioPlex,STRINGDB
CD70
Tbio
Novelty:  0.00420393
p_int:  0.983811138
p_ni:  0.016188633
p_wrong:  2.29e-7
Data Source:  BioPlex
RUFY3
Tbio
Novelty:  0.1517817
p_int:  0.983485448
p_ni:  0.016514552
Score:  0.693
Data Source:  BioPlex,STRINGDB
EPHA3
Tchem
Family:  Kinase
Novelty:  0.00466013
Score:  0.819
Data Source:  STRINGDB
RUFY4
Tbio
Novelty:  0.95990073
Score:  0.761
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.47

PubMed score by year
PubTator Score  0.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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