You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NLRP7
NACHT, LRR and PYD domains-containing protein 7

Protein Summary
Description
Inhibits CASP1/caspase-1-dependent IL1B secretion. This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328092
  • ENSP00000329568
  • ENSG00000167634
  • ENST00000340844
  • ENSP00000339491
  • ENST00000588756
  • ENSP00000467123
  • ENST00000590030
  • ENSP00000465520
  • ENST00000592784
  • ENSP00000468706
  • ENST00000610424
  • ENSP00000482887
  • ENSG00000274571
  • ENST00000610790
  • ENSP00000478726
  • ENST00000610853
  • ENSP00000478890
  • ENST00000610981
  • ENSP00000479459
  • ENSG00000277776
  • ENST00000611597
  • ENSP00000481117
  • ENST00000613233
  • ENSP00000483203
  • ENST00000614879
  • ENSP00000484444
  • ENSG00000277071
  • ENST00000615426
  • ENSP00000484426
  • ENST00000615699
  • ENSP00000480449
  • ENSG00000277786
  • ENST00000618261
  • ENSP00000483353
  • ENSG00000277179
  • ENST00000618343
  • ENSP00000480226
  • ENSG00000274174
  • ENST00000618672
  • ENSP00000481452
  • ENST00000618740
  • ENSP00000484808
  • ENST00000618995
  • ENSP00000481809
  • ENSG00000276804
  • ENST00000620183
  • ENSP00000480034
  • ENST00000620820
  • ENSP00000482551
  • ENST00000621238
  • ENSP00000481395
  • ENST00000621584
  • ENSP00000479541
  • ENSG00000275483
  • ENST00000622199
  • ENSP00000482194

Symbol
  • NALP7
  • NOD12
  • PYPAF3
  • HYDM
  • PAN7
  • NALP7
  • NOD12
  • PYPAF3
  • CLR19.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.73
protein domain
0.58
biological term
0.57
cell line
0.52
cellular component
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.6   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.6   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
PYCARD
Tbio
Novelty:  0.00719985
Score:  0.914
Data Source:  STRINGDB
KHDC3L
Tbio
Novelty:  0.0343295
Score:  0.837
Data Source:  STRINGDB
MEFV
Tbio
Novelty:  0.00074419
Score:  0.788
Data Source:  STRINGDB
NLRC4
Tbio
Novelty:  0.0032237
Score:  0.769
Data Source:  STRINGDB
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
Score:  0.726
Data Source:  STRINGDB
AIM2
Tbio
Novelty:  0.00360474
Score:  0.694
Data Source:  STRINGDB
PEG3
Tbio
Family:  TF
Novelty:  0.00367006
Score:  0.629
Data Source:  STRINGDB
IL18
Tbio
Novelty:  0.00022844
Score:  0.613
Data Source:  STRINGDB
ZFP57
Tbio
Family:  TF
Novelty:  0.02250344
Score:  0.592
Data Source:  STRINGDB
IL1B
Tclin
Novelty:  0.0000308
Score:  0.584
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (162)
Items per page:
1 – 5 of 162
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet reactivity measurement
1
1
1
92.9
platelet reactivity measurement
1
1
1
92.9
platelet reactivity measurement
1
1
1
92.9
platelet reactivity measurement
1
1
1
92.9
platelet reactivity measurement
1
1
1
92.9
Items per page:
1 – 5 of 162
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet reactivity measurement
1
92.9
platelet reactivity measurement
1
92.9
platelet reactivity measurement
1
92.9
platelet reactivity measurement
1
92.9
platelet reactivity measurement
1
92.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 181.60
PubMed score by year
PubTator Score 75.37
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title