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Tbio
NELFB
Negative elongation factor B

Protein Summary
Description
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1. May be able to induce chromatin unfolding. NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Nari ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000634710
  • ENSP00000489248
  • ENSG00000188986

Symbol
  • COBRA1
  • KIAA1182
  • COBRA1
  • NELF-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
histone modification site profile
0.91
co-expressed gene
0.89
pathway
0.78
hub protein
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.16   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.16   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
NELFE
Tbio
Novelty:  0.02136256
p_int:  0.999999983
p_ni:  1e-8
p_wrong:  7e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NELFA
Tbio
Novelty:  0.09727823
p_int:  0.99999998
p_ni:  1.7e-8
p_wrong:  3e-9
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
FECH
Tchem
Family:  Enzyme
Novelty:  0.00282289
p_int:  0.999994081
p_ni:  0.000005919
Score:  0.768
Data Source:  BioPlex,STRINGDB
CYP2J2
Tchem
Novelty:  0.00534181
p_int:  0.999879617
p_ni:  0.000120383
Data Source:  BioPlex
ANK1
Tbio
Novelty:  0.00225305
p_int:  0.932192192
p_ni:  0.067047519
p_wrong:  0.000760289
Score:  0.224
Data Source:  BioPlex,STRINGDB
NELFCD
Tbio
Novelty:  0.00094754
Score:  0.994
Data Source:  Reactome,STRINGDB
SUPT5H
Tbio
Novelty:  0.00775042
Score:  0.992
Data Source:  Reactome,STRINGDB
NCBP1
Tbio
Novelty:  0.01228885
Score:  0.99
Data Source:  Reactome,STRINGDB
SUPT4H1
Tbio
Novelty:  0.0127914
Score:  0.988
Data Source:  Reactome,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.982
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (32)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

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1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Disease
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Reactome
Formation of RNA Pol II elongation complex
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Disease
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of RNA Pol II elongation complex
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
4
2
3
1.1
96.2
glomerular filtration rate
4
4
5
89.9
mathematical ability
4
2
4
85.7
creatinine measurement
2
4
5
81.6
circadian rhythm
2
1
1
1.1
73.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
1.1
96.2
glomerular filtration rate
5
89.9
mathematical ability
4
85.7
creatinine measurement
5
81.6
circadian rhythm
1
1.1
73.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
negative elongation factor complex member B
VGNC:13923
736409
Macaque
negative elongation factor complex member B
704966
Mouse
MGI:1931035
58202
Rat
RGD:1307832
311796
Dog
negative elongation factor complex member B
VGNC:43737
491230
Species
Name
OMA
EggNOG
Inparanoid
Chimp
negative elongation factor complex member B
Macaque
negative elongation factor complex member B
Mouse
Rat
Dog
negative elongation factor complex member B
Publication Statistics
PubMed Score 35.16
PubMed score by year
PubTator Score 10.85
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title