Tbio IGFBPL1 Insulin-like growth factor-binding protein-like 1

Protein Summary

Description

IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.

Uniprot Accession IDs

• Q8WX77

Gene Name

• IGFBPL1

Ensembl ID

• ENST00000377694
• ENSP00000366923
• ENSG00000137142

Symbol

• IGFBPRP4
• IGFBPRP4
• IGFBP-RP4
• bA113O24.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
PubMedID	0.64
gene perturbation	0.59
virus perturbation	0.55
transcription factor binding site profile	0.44

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.27   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 45   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.27   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0