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Tdark
ABCA10
ATP-binding cassette sub-family A member 10

Protein Summary
Description
Probable transporter which may play a role in macrophage lipid homeostasis. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269081
  • ENSP00000269081
  • ENSG00000154263
  • ENST00000522406
  • ENSP00000429853
  • ENST00000523512
  • ENSP00000429945

Symbol
  • EST698739
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
microRNA
0.92
protein domain
0.73
tissue
0.64
cell type or tissue
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.19   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.19   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
8
7
14
1.9
99.3
apolipoprotein B measurement
2
5
6
97.7
total cholesterol measurement
4
4
7
95.9
corneal hysteresis
2
2
3
93.9
serum albumin measurement
1
2
2
88.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
14
1.9
99.3
apolipoprotein B measurement
6
97.7
total cholesterol measurement
7
95.9
corneal hysteresis
3
93.9
serum albumin measurement
2
88.6
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Horse
ATP binding cassette subfamily A member 10
VGNC:49429
100062390
Anole lizard
ATP-binding cassette sub-family A member 10
100564947
Xenopus
ATP binding cassette subfamily A member 10 [Source:Xenbase;Acc:XB-GENE-6464279]
Species
Name
OMA
EggNOG
Inparanoid
Horse
ATP binding cassette subfamily A member 10
Anole lizard
ATP-binding cassette sub-family A member 10
Xenopus
ATP binding cassette subfamily A member 10 [Source:Xenbase;Acc:XB-GENE-6464279]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WWZ4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
ABC transporters in lipid homeostasis (R-HSA-1369062)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
Transport of small molecules
Protein-Protein Interactions (23)
1 – 10 of 23
ABCF3
Tdark
Family:  Transporter
Novelty:  0.21595418
Score:  0.59
Data Source:  STRINGDB
ABCC9
Tclin
Family:  Transporter
Novelty:  0.01490297
Score:  0.558
Data Source:  STRINGDB
MAP2K6
Tchem
Family:  Kinase
Novelty:  0.00569655
Score:  0.54
Data Source:  STRINGDB
DEFB133
Tdark
Novelty:  8.07692308
Score:  0.511
Data Source:  STRINGDB
VSIG10L
Tdark
Novelty:  0.8815667
Score:  0.51
Data Source:  STRINGDB
ABCC11
Tbio
Family:  Transporter
Novelty:  0.01382192
Score:  0.495
Data Source:  STRINGDB
SLC22A24
Tdark
Family:  Transporter
Novelty:  1.03601293
Score:  0.494
Data Source:  STRINGDB
FAM187B
Tdark
Novelty:  0.59092623
Score:  0.477
Data Source:  STRINGDB
WDR89
Tdark
Novelty:  1.32691886
Score:  0.471
Data Source:  STRINGDB
OR7G3
Tdark
Family:  oGPCR
Novelty:  1.25607075
Score:  0.463
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.19

PubMed score by year
PubTator Score  2.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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