You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EDARADD
Ectodysplasin-A receptor-associated adapter protein

Protein Summary
Description
Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B. This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334232
  • ENSP00000335076
  • ENSG00000186197
  • ENST00000359362
  • ENSP00000352320

Symbol
  • ED3
  • EDA3
  • ECTD11A
  • ECTD11B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
cell type or tissue
0.74
transcription factor
0.57
gene perturbation
0.55
cell line
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.43   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.43   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
1
1
0
1.1
45
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
0
1.1
45
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EDAR associated death domain
VGNC:11759
104004808
Macaque
EDAR associated death domain
710637
Mouse
MGI:1931001
171211
Rat
RGD:1564010
498769
Dog
EDAR associated death domain
VGNC:40191
100856497
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EDAR associated death domain
Macaque
EDAR associated death domain
Mouse
Rat
Dog
EDAR associated death domain
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WWZ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (24)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (48)
1 – 10 of 48
EDAR
Tbio
Novelty: 0.00433299
Score: 0.992
Data Source: Reactome,STRINGDB
EDA
Tbio
Novelty: 0.00352464
Score: 0.969
Data Source: Reactome,STRINGDB
NR2C2
Tchem
Family: NR
Novelty: 0.00392355
Score: 0.889
Data Source: STRINGDB
TMEM242
Tdark
Novelty: 0.99055845
Score: 0.777
Data Source: STRINGDB
CNOT1
Tbio
Novelty: 0.00362753
Score: 0.731
Data Source: STRINGDB
HEATR1
Tbio
Novelty: 0.10365788
Score: 0.7
Data Source: STRINGDB
EDA2R
Tbio
Novelty: 0.03463669
Score: 0.698
Data Source: STRINGDB
MAP3K7
Tchem
Family: Kinase
Novelty: 0.00540177
Score: 0.691
Data Source: STRINGDB
PUM2
Tbio
Novelty: 0.01849765
Score: 0.689
Data Source: STRINGDB
PUM1
Tbio
Novelty: 0.01536723
Score: 0.689
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.43

PubMed score by year
PubTator Score  22.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: