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Tbio
IL1F10
Interleukin-1 family member 10

Protein Summary
Description
Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341010
  • ENSP00000341794
  • ENSG00000136697
  • ENST00000393197
  • ENSP00000376893

Symbol
  • FIL1T
  • IL1HY2
  • IL38
  • IL-38
  • FKSG75
  • IL1HY2
  • IL-1HY2
  • IL1-theta
  • FIL1-theta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
protein domain
0.58
virus perturbation
0.55
phenotype
0.51
cell line
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.41   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.41   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
N4BP1
Tbio
Novelty:  0.10170063
p_int:  0.999932702
p_ni:  4.46e-7
p_wrong:  0.000066851
Data Source:  BioPlex
ISCA1
Tbio
Novelty:  0.01288069
p_int:  0.999628924
p_ni:  0.000371075
p_wrong:  1e-9
Data Source:  BioPlex
OAZ3
Tbio
Family:  Enzyme
Novelty:  0.02374168
p_int:  0.999103925
p_ni:  0.000001264
p_wrong:  0.000894812
Score:  0.303
Data Source:  BioPlex,STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.989491035
p_ni:  0.010508965
Data Source:  BioPlex
KLHL18
Tdark
Novelty:  0.52915213
p_int:  0.978934231
p_ni:  0.020801067
p_wrong:  0.000264702
Data Source:  BioPlex
KLHL42
Tdark
Novelty:  0.25822395
p_int:  0.970766807
p_ni:  0.029232991
p_wrong:  2.02e-7
Data Source:  BioPlex
KLHL24
Tbio
Novelty:  0.04032749
p_int:  0.820684494
p_ni:  0.179315504
p_wrong:  2e-9
Data Source:  BioPlex
IL1RL2
Tbio
Novelty:  0.0156461
Score:  0.983
Data Source:  Reactome,STRINGDB
IL36B
Tbio
Novelty:  0.05952789
Score:  0.973
Data Source:  STRINGDB
IL1RAPL1
Tbio
Novelty:  0.01364357
Score:  0.939
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-36 pathway
Reactome
Interleukin-38 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-36 pathway
Interleukin-38 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
7
8
11
99.2
interleukin 1 receptor antagonist measurement
2
3
3
96.2
interleukin-1 beta measurement
2
11
11
94.7
neutrophil percentage of leukocytes
2
2
2
90.7
neutrophil count
3
2
3
89.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
11
99.2
interleukin 1 receptor antagonist measurement
3
96.2
interleukin-1 beta measurement
11
94.7
neutrophil percentage of leukocytes
2
90.7
neutrophil count
3
89.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 family member 10
VGNC:48882
470487
Mouse
MGI:2652548
215274
Rat
RGD:1305635
362077
Dog
interleukin 1 family member 10
VGNC:49108
611873
Horse
interleukin 1 family member 10
VGNC:51325
100052532
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 family member 10
Mouse
Rat
Dog
interleukin 1 family member 10
Horse
interleukin 1 family member 10
Publication Statistics
PubMed Score 77.41
PubMed score by year
PubTator Score 29.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title