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Tchem
SLC5A11
Sodium/myo-inositol cotransporter 2

Protein Summary
Description
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney. Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive active transport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002) [PubMed 12039040].[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347898
  • ENSP00000289932
  • ENSG00000158865
  • ENST00000424767
  • ENSP00000416782
  • ENST00000449109
  • ENSP00000389606
  • ENST00000545376
  • ENSP00000441384
  • ENST00000565769
  • ENSP00000457179
  • ENST00000567758
  • ENSP00000454401
  • ENST00000568579
  • ENSP00000456234
  • ENST00000569071
  • ENSP00000456376

Symbol
  • KST1
  • SLGTX
  • SMIT2
  • KST1
  • RKST1
  • SGLT6
  • SMIT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
transcription factor
0.71
cell line
0.66
tissue
0.61
PubMedID
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.7   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.7   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (20)
LINGO1
Tbio
Novelty:  0.00778085
p_int:  0.930452727
p_ni:  0.069546552
p_wrong:  7.21e-7
Score:  0.402
Data Source:  BioPlex,STRINGDB
SLC2A13
Tbio
Family:  Transporter
Novelty:  0.04641021
Score:  0.687
Data Source:  STRINGDB
KPNA3
Tbio
Novelty:  0.02173035
Score:  0.667
Data Source:  STRINGDB
SLC13A3
Tbio
Family:  Transporter
Novelty:  0.02627177
Score:  0.635
Data Source:  STRINGDB
SLC13A4
Tbio
Family:  Transporter
Novelty:  0.01859297
Score:  0.6
Data Source:  STRINGDB
ITPK1
Tbio
Family:  Kinase
Novelty:  0.02790263
Score:  0.597
Data Source:  STRINGDB
SLC2A2
Tchem
Family:  Transporter
Novelty:  0.00103579
Score:  0.588
Data Source:  STRINGDB
SLC2A5
Tbio
Family:  Transporter
Novelty:  0.0032733
Score:  0.558
Data Source:  STRINGDB
SGK2
Tchem
Family:  Kinase
Novelty:  0.06488042
Score:  0.534
Data Source:  STRINGDB
SLC3A1
Tbio
Family:  Transporter
Novelty:  0.003328
Score:  0.519
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Inositol transporters (R-HSA-429593)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Inositol transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
2
2
85
mean platelet volume
2
1
2
81.1
appendicular lean mass
4
1
4
76.5
alcohol consumption measurement
3
1
3
65.6
visceral adipose tissue measurement
1
1
1
59.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
85
mean platelet volume
2
81.1
appendicular lean mass
4
76.5
alcohol consumption measurement
3
65.6
visceral adipose tissue measurement
1
59.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 11
VGNC:9015
453998
Macaque
solute carrier family 5 member 11
701816
Mouse
MGI:1919316
233836
Rat
RGD:621410
252854
Dog
solute carrier family 5 member 11
VGNC:46444
489965
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 11
Macaque
solute carrier family 5 member 11
Mouse
Rat
Dog
solute carrier family 5 member 11
Publication Statistics
PubMed Score 72.70
PubMed score by year
PubTator Score 13.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title