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Tchem
SLC5A11
Sodium/myo-inositol cotransporter 2

Protein Summary
Description
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney. Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive active transport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002) [PubMed 12039040].[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347898
  • ENSP00000289932
  • ENSG00000158865
  • ENST00000424767
  • ENSP00000416782
  • ENST00000449109
  • ENSP00000389606
  • ENST00000545376
  • ENSP00000441384
  • ENST00000565769
  • ENSP00000457179
  • ENST00000567758
  • ENSP00000454401
  • ENST00000568579
  • ENSP00000456234
  • ENST00000569071
  • ENSP00000456376

Symbol
  • KST1
  • SLGTX
  • SMIT2
  • KST1
  • RKST1
  • SGLT6
  • SMIT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
transcription factor
0.71
cell line
0.66
tissue
0.61
PubMedID
0.6


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.32   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.32   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dapagliflozin
chemical structure image
Active Ligands (1)
1 – 1 of 1
CHEMBL245067
chemical structure image
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 11
VGNC:9015
453998
Macaque
solute carrier family 5 member 11
701816
Mouse
MGI:1919316
233836
Rat
RGD:621410
252854
Dog
solute carrier family 5 member 11
VGNC:46444
489965
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 11
Macaque
solute carrier family 5 member 11
Mouse
Rat
Dog
solute carrier family 5 member 11
Pathways (18)
Inositol transporters (R-HSA-429593)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Inositol transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (20)
1 – 10 of 20
LINGO1
Tbio
Novelty: 0.00778085
p_int: 0.930452727
p_ni: 0.069546552
p_wrong: 7.21e-7
Score: 0.402
Data Source: BioPlex,STRINGDB
SLC2A13
Tbio
Family: Transporter
Novelty: 0.04641021
Score: 0.687
Data Source: STRINGDB
KPNA3
Tbio
Novelty: 0.02173035
Score: 0.667
Data Source: STRINGDB
SLC13A3
Tbio
Family: Transporter
Novelty: 0.02627177
Score: 0.635
Data Source: STRINGDB
SLC13A4
Tbio
Family: Transporter
Novelty: 0.01859297
Score: 0.6
Data Source: STRINGDB
ITPK1
Tbio
Family: Kinase
Novelty: 0.02790263
Score: 0.597
Data Source: STRINGDB
SLC2A2
Tchem
Family: Transporter
Novelty: 0.00103579
Score: 0.588
Data Source: STRINGDB
SLC2A5
Tbio
Family: Transporter
Novelty: 0.0032733
Score: 0.558
Data Source: STRINGDB
SGK2
Tchem
Family: Kinase
Novelty: 0.06488042
Score: 0.534
Data Source: STRINGDB
SLC3A1
Tbio
Family: Transporter
Novelty: 0.003328
Score: 0.519
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.32

PubMed score by year
PubTator Score  13.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer