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Tbio
GAB3
GRB2-associated-binding protein 3

Protein Summary
Description
This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369568
  • ENSP00000358581
  • ENSG00000160219
  • ENST00000369575
  • ENSP00000358588
  • ENST00000424127
  • ENSP00000399588
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.77
histone modification site profile
0.67
tissue sample
0.62
microRNA
0.53
hub protein
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.39   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.39   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (19)
1 – 10 of 19
A1BG
Tbio
Novelty:  0.00508743
Score:  0.732
Data Source:  STRINGDB
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
Score:  0.693
Data Source:  STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.669
Data Source:  STRINGDB
CSF1
Tbio
Novelty:  0.0005221
Score:  0.666
Data Source:  STRINGDB
MTDH
Tbio
Novelty:  0.00342872
Score:  0.558
Data Source:  STRINGDB
GRAP2
Tbio
Novelty:  0.00503901
Score:  0.549
Data Source:  STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.529
Data Source:  STRINGDB
CSF1R
Tclin
Family:  Kinase
Novelty:  0.00064143
Score:  0.523
Data Source:  STRINGDB
ATF7
Tbio
Family:  TF
Novelty:  0.01470313
Score:  0.517
Data Source:  STRINGDB
PLEK
Tbio
Novelty:  0.00074263
Score:  0.493
Data Source:  STRINGDB
Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
2
2
88.8
hematocrit
1
1
1
50.6
leukocyte count
1
1
1
50.6
hemoglobin measurement
1
1
1
50.6
erythrocyte count
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
88.8
hematocrit
1
50.6
leukocyte count
1
50.6
hemoglobin measurement
1
50.6
erythrocyte count
1
50.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GRB2 associated binding protein 3
VGNC:2745
473837
Macaque
GRB2 associated binding protein 3
701859
Mouse
MGI:2387324
210710
Dog
GRB2 associated binding protein 3
VGNC:54143
492262
Horse
GRB2 associated binding protein 3
VGNC:18186
100063152
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GRB2 associated binding protein 3
Macaque
GRB2 associated binding protein 3
Mouse
Dog
GRB2 associated binding protein 3
Horse
GRB2 associated binding protein 3
Publication Statistics
PubMed Score 14.39
PubMed score by year
PubTator Score 7.80
PubTator score by year