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Tbio
RASSF5
Ras association domain-containing protein 5

Protein Summary
Description
Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000577571
  • ENSP00000462576
  • ENSG00000266094
  • ENST00000579436
  • ENSP00000462099
  • ENST00000580449
  • ENSP00000462544

Symbol
  • NORE1
  • RAPL
  • RAPL
  • Maxp1
  • NORE1
  • NORE1A
  • NORE1B
  • RASSF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.83
transcription factor
0.77
transcription factor binding site profile
0.77
interacting protein
0.74
histone modification site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.07   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.07   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
STK4
Tchem
Family:  Kinase
Novelty:  0.02104423
Score:  0.998
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.985
Data Source:  STRINGDB
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
Score:  0.974
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.957
Data Source:  STRINGDB
RAP1B
Tbio
Family:  Enzyme
Novelty:  0.00627538
Score:  0.934
Data Source:  STRINGDB
STK3
Tchem
Family:  Kinase
Novelty:  0.0529257
Score:  0.933
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.927
Data Source:  STRINGDB
RRAS2
Tbio
Family:  Enzyme
Novelty:  0.01870067
Score:  0.926
Data Source:  STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
Score:  0.924
Data Source:  STRINGDB
MRAS
Tbio
Family:  Enzyme
Novelty:  0.01544981
Score:  0.916
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
Pathways (17)
Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Non-small cell lung cancer
KEGG
Rap1 signaling pathway
KEGG
Ras signaling pathway
KEGG
Pathways in cancer
KEGG
Cellular senescence
Name
Explore in Pharos
Explore in Source
Non-small cell lung cancer
Rap1 signaling pathway
Ras signaling pathway
Pathways in cancer
Cellular senescence
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
1
3
78.3
3
3
2
1
64.3
serum non-albumin protein measurement
1
1
1
57.3
mean corpuscular hemoglobin concentration
1
1
1
55.2
eosinophil percentage of leukocytes
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
78.3
2
1
64.3
serum non-albumin protein measurement
1
57.3
mean corpuscular hemoglobin concentration
1
55.2
eosinophil percentage of leukocytes
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1926375
54354
Rat
RGD:621694
54355
Dog
Ras association domain family member 5
VGNC:45382
607454
Horse
Ras association domain family member 5
VGNC:22212
100051000
Cow
Ras association domain family member 5
VGNC:33761
539767
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
Ras association domain family member 5
Horse
Ras association domain family member 5
Cow
Ras association domain family member 5
Publication Statistics
PubMed Score 104.07
PubMed score by year
PubTator Score 64.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title