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Tbio
RASSF5
Ras association domain-containing protein 5

Protein Summary
Description
Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000577571
  • ENSP00000462576
  • ENSG00000266094
  • ENST00000579436
  • ENSP00000462099
  • ENST00000580449
  • ENSP00000462544

Symbol
  • NORE1
  • RAPL
  • RAPL
  • Maxp1
  • NORE1
  • NORE1A
  • NORE1B
  • RASSF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.83
transcription factor
0.77
transcription factor binding site profile
0.77
interacting protein
0.74
histone modification site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.21   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.21   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Non-small cell lung cancer
KEGG
Rap1 signaling pathway
KEGG
Ras signaling pathway
KEGG
Pathways in cancer
KEGG
Cellular senescence
Name
Explore in Pharos
Explore in Source
Non-small cell lung cancer
Rap1 signaling pathway
Ras signaling pathway
Pathways in cancer
Cellular senescence
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (89)
1 – 10 of 89
STK4
Tchem
Family: Kinase
Novelty: 0.02104423
Score: 0.998
Data Source: STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.985
Data Source: STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
Score: 0.974
Data Source: STRINGDB
KRAS
Tchem
Family: Enzyme
Novelty: 0.00013856
Score: 0.957
Data Source: STRINGDB
RAP1B
Tbio
Family: Enzyme
Novelty: 0.00627538
Score: 0.934
Data Source: STRINGDB
STK3
Tchem
Family: Kinase
Novelty: 0.0529257
Score: 0.933
Data Source: STRINGDB
NRAS
Tchem
Family: Enzyme
Novelty: 0.00080922
Score: 0.927
Data Source: STRINGDB
RRAS2
Tbio
Family: Enzyme
Novelty: 0.01870067
Score: 0.926
Data Source: STRINGDB
RRAS
Tbio
Family: Enzyme
Novelty: 0.00786502
Score: 0.924
Data Source: STRINGDB
MRAS
Tbio
Family: Enzyme
Novelty: 0.01544981
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  103.21

PubMed score by year
PubTator Score  64.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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