Protein Summary
May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids. The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2009]
- ENST00000325935
- ENSP00000320318
- ENSG00000204099
- ENST00000391969
- ENSP00000375830
- ENST00000404257
- ENSP00000385149
- ENST00000405370
- ENSP00000384804
- ENST00000407683
- ENSP00000385402
- ENST00000616490
- ENSP00000482722
- ENSG00000277926
- ENST00000618866
- ENSP00000483726
- ENST00000621851
- ENSP00000478409
- ENST00000626600
- ENSP00000485701
- ENST00000630923
- ENSP00000486602
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.74 | ||
pathway | 0.73 | ||
cell type or tissue | 0.72 | ||
virus perturbation | 0.72 | ||
tissue sample | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 49.64 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 155 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 49.64 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 155 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0