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Tbio
STAB2
Stabilin-2

Protein Summary
Description
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS. This gene encodes a large, tran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388887
  • ENSP00000373539
  • ENSG00000136011

Symbol
  • FEEL2
  • FELL
  • FEX2
  • HARE
  • FEX2
  • HARE
  • FEEL2
  • FELL2
  • FELE-2
  • SCARH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
pathway
0.94
trait
0.86
molecular function
0.73
cell type or tissue
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.61   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.61   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
von Willebrand factor measurement
3
1
2
2.4
93
factor VIII measurement
1
1
2
76.7
monocyte count
1
1
1
54.1
response to drug
1
1
0
4
21.9
adverse effect
1
1
0
4
21.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
von Willebrand factor measurement
2
2.4
93
factor VIII measurement
2
76.7
monocyte count
1
54.1
response to drug
0
4
21.9
adverse effect
0
4
21.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stabilin 2
VGNC:5602
452186
Mouse
MGI:2178743
192188
Rat
RGD:628822
282580
Dog
stabilin 2
VGNC:46869
100687903
Horse
stabilin 2
VGNC:23645
100067500
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stabilin 2
Mouse
Rat
Dog
stabilin 2
Horse
stabilin 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WWQ8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Glycosaminoglycan metabolism
Reactome
Hyaluronan metabolism
Reactome
Hyaluronan uptake and degradation
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Glycosaminoglycan metabolism
Hyaluronan metabolism
Hyaluronan uptake and degradation
Metabolism
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (56)
1 – 10 of 56
LYVE1
Tbio
Novelty: 0.00186825
Score: 0.972
Data Source: STRINGDB
HMMR
Tbio
Novelty: 0.0039196
Score: 0.945
Data Source: STRINGDB
CD44
Tbio
Novelty: 0.00011321
Score: 0.93
Data Source: STRINGDB
HYAL2
Tbio
Family: Enzyme
Novelty: 0.00740331
Score: 0.918
Data Source: Reactome,STRINGDB
APOB
Tchem
Novelty: 0.00008247
Score: 0.913
Data Source: STRINGDB
CHP1
Tbio
Novelty: 0.01299969
Score: 0.902
Data Source: Reactome,STRINGDB
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00096678
Score: 0.902
Data Source: Reactome,STRINGDB
EGFLAM
Tbio
Novelty: 0.02955802
Score: 0.802
Data Source: STRINGDB
ADGRB1
Tbio
Family: GPCR
Novelty: 0.01861364
Score: 0.736
Data Source: STRINGDB
GULP1
Tbio
Novelty: 0.01367525
Score: 0.728
Data Source: STRINGDB
Publication Statistics
PubMed Score  84.61

PubMed score by year
PubTator Score  53.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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