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Tbio
PHIP
PH-interacting protein

Protein Summary
Description
Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. This gene encodes a protein that binds to the insulin receptor substrate 1 protein and regulates glucose transporter translocation in skeletal muscle cells. The encoded protein may also regulate growth and survival of pancreatic beta cells. Elevated copy number of this gene may be associated with melanoma severity and the encoded protein may promote melanoma metastasis in human patients. [provided by RefSeq, Oct 2016]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.96
virus perturbation
0.94
protein domain
0.92
biological process
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 539.84   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 539.84   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (86)
1 – 10 of 86
ATRX
Tbio
Novelty: 0.0012597
Score: 0.88
Data Source: STRINGDB
NIPBL
Tbio
Novelty: 0.00501923
Score: 0.848
Data Source: STRINGDB
BDP1
Tbio
Novelty: 0.00576319
Score: 0.845
Data Source: STRINGDB
BRWD1
Tbio
Family: Epigenetic
Novelty: 0.1631913
Score: 0.825
Data Source: STRINGDB
SCAF11
Tdark
Novelty: 0.01139854
Score: 0.781
Data Source: STRINGDB
IRS1
Tbio
Novelty: 0.00061858
Score: 0.774
Data Source: STRINGDB
IRAK1BP1
Tbio
Family: Enzyme
Novelty: 0.03517514
Score: 0.748
Data Source: STRINGDB
ATAD2B
Tchem
Family: Epigenetic
Novelty: 1.42465753
Score: 0.748
Data Source: STRINGDB
CEP350
Tbio
Novelty: 0.09631923
Score: 0.733
Data Source: STRINGDB
HSD17B6
Tbio
Family: Enzyme
Novelty: 0.00841501
Score: 0.731
Data Source: STRINGDB
Publication Statistics
PubMed Score  539.84

PubMed score by year
PubTator Score  34.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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