Tbio CYGB Cytoglobin

Protein Summary

Description

May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer. This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• Q8WWM9
• Q541Y7
• Q8N2X5

Gene Name

• CYGB

Ensembl ID

• ENST00000293230
• ENSP00000293230
• ENSG00000161544

Symbol

• STAP
• HGB
• STAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.73
disease	0.7
cell line	0.69
PubMedID	0.66
biological term	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2597.39   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 275   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2597.39   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0