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Tbio
ATXN2L
Ataxin-2-like protein

Protein Summary
Description
Involved in the regulation of stress granule and P-body formation. This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325215
  • ENSP00000315650
  • ENSG00000168488
  • ENST00000336783
  • ENSP00000338718
  • ENST00000340394
  • ENSP00000341459
  • ENST00000382686
  • ENSP00000372133
  • ENST00000395547
  • ENSP00000378917
  • ENST00000570200
  • ENSP00000454516

Symbol
  • A2D
  • A2LG
  • A2LP
  • A2RP
  • A2D
  • A2LG
  • A2LP
  • A2RP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
0.98
transcription factor binding site profile
0.94
ligand (protein) perturbation
0.83
transcription factor
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.84   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.84   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
1
1
95
self reported educational attainment
2
2
1
7.6
93.6
intelligence
5
3
1
5.7
90.2
grip strength measurement
1
1
1
79.3
body mass index
3
1
4
64.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
95
self reported educational attainment
1
7.6
93.6
intelligence
1
5.7
90.2
grip strength measurement
1
79.3
body mass index
4
64.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ataxin 2 like
VGNC:8959
454017
Macaque
ataxin 2 like
708359
Mouse
MGI:2446242
233871
Rat
RGD:1565868
361649
Dog
ataxin 2 like
VGNC:38302
489951
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ataxin 2 like
Macaque
ataxin 2 like
Mouse
Rat
Dog
ataxin 2 like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WWM7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (80)
1 – 10 of 80
NUFIP2
Tbio
Novelty: 0.09366649
p_int: 0.999954885
p_ni: 0.000045115
Score: 0.904
Data Source: BioPlex,STRINGDB
MCRIP2
Tdark
Novelty: 1.50465727
p_int: 0.999730532
p_ni: 0.000269468
Score: 0.445
Data Source: BioPlex,STRINGDB
G3BP2
Tbio
Family: Enzyme
Novelty: 0.04786241
p_int: 0.978818471
p_ni: 0.021181529
Score: 0.915
Data Source: BioPlex,STRINGDB
LSM12
Tbio
Novelty: 0.0593959
Score: 0.976
Data Source: STRINGDB
PABPC1
Tbio
Novelty: 0.00197523
Score: 0.938
Data Source: STRINGDB
PABPC4
Tbio
Novelty: 0.06854984
Score: 0.907
Data Source: STRINGDB
PABPC3
Tbio
Novelty: 0.13551529
Score: 0.873
Data Source: STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
Score: 0.86
Data Source: STRINGDB
DDX6
Tbio
Family: Enzyme
Novelty: 0.01032357
Score: 0.843
Data Source: STRINGDB
PABPC1L
Tbio
Novelty: 0.04037574
Score: 0.786
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.84

PubMed score by year
PubTator Score  19.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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