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Tbio
SPIRE2
Protein spire homolog 2

Protein Summary
Description
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378247
  • ENSP00000367494
  • ENSG00000204991
  • ENST00000393062
  • ENSP00000376782

Symbol
  • KIAA1832
  • SPIR2
  • Spir-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
histone modification site profile
0.77
transcription factor
0.74
transcription factor binding site profile
0.71
cell type or tissue
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.2   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.2   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
3
4
0
1.5
94.5
suntan
1
1
1
87.9
skin aging measurement
1
1
1
66.8
1
1
0
1.1
65.9
1
1
0
1.1
65.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.5
94.5
suntan
1
87.9
skin aging measurement
1
66.8
0
1.1
65.9
0
1.1
65.9
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (58)
1 – 10 of 58
BCL7A
Tbio
Novelty: 0.07026394
p_int: 0.999999933
p_ni: 1.2e-8
p_wrong: 5.5e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
ACTB
Tbio
Novelty: 0.00006048
p_int: 0.999999137
p_ni: 8.58e-7
p_wrong: 6e-9
Score: 0.423
Data Source: BioPlex,STRINGDB
TMOD3
Tbio
Novelty: 0.04744699
p_int: 0.996385552
p_ni: 0.000001825
p_wrong: 0.003612623
Score: 0.201
Data Source: BioPlex,STRINGDB
MYO5A
Tbio
Novelty: 0.00373224
Score: 0.968
Data Source: STRINGDB
FMN2
Tbio
Novelty: 0.02031944
Score: 0.889
Data Source: STRINGDB
MYO5B
Tbio
Novelty: 0.01302142
Score: 0.875
Data Source: STRINGDB
TCF25
Tbio
Novelty: 0.08961823
Score: 0.808
Data Source: STRINGDB
PLEKHJ1
Tdark
Novelty: 1.44399298
Score: 0.781
Data Source: STRINGDB
MYO5C
Tbio
Novelty: 0.05680943
Score: 0.777
Data Source: STRINGDB
FMN1
Tbio
Novelty: 0.00130542
Score: 0.748
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.20

PubMed score by year
PubTator Score  7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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