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Tbio
SLC44A1
Choline transporter-like protein 1

Protein Summary
Description
Choline transporter. May be involved in membrane synthesis and myelin production.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374720
  • ENSP00000363852
  • ENSG00000070214
  • ENST00000374723
  • ENSP00000363855
  • ENST00000374724
  • ENSP00000363856
  • ENST00000470972
  • ENSP00000433072

Symbol
  • CD92
  • CDW92
  • CTL1
  • CD92
  • CTL1
  • CDW92
  • CHTL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
transcription factor binding site profile
0.97
small molecule perturbation
0.95
virus perturbation
0.95
PubMedID
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.28   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.28   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.999976264
p_ni:  0.000023686
p_wrong:  5.1e-8
Data Source:  BioPlex
TSPAN17
Tdark
Novelty:  0.51639684
p_int:  0.999969471
p_ni:  0.000030178
p_wrong:  3.5e-7
Score:  0.196
Data Source:  BioPlex,STRINGDB
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.999953664
p_ni:  0.0000166
p_wrong:  0.000029736
Data Source:  BioPlex
NT5E
Tchem
Family:  Enzyme
Novelty:  0.00083237
p_int:  0.999952733
p_ni:  0.000047266
p_wrong:  1e-9
Data Source:  BioPlex
TMEM128
Tdark
Novelty:  5.15874803
p_int:  0.99995118
p_ni:  0.000036385
p_wrong:  0.000012435
Score:  0.165
Data Source:  BioPlex,STRINGDB
TMEM159
Tdark
Novelty:  0.22237677
p_int:  0.99963129
p_ni:  0.000349774
p_wrong:  0.000018936
Data Source:  BioPlex
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.999604477
p_ni:  0.000384292
p_wrong:  0.000011231
Data Source:  BioPlex
PTH1R
Tclin
Family:  GPCR
Novelty:  0.00413989
p_int:  0.999412085
p_ni:  0.000360762
p_wrong:  0.000227153
Score:  0.183
Data Source:  BioPlex,STRINGDB
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.999308263
p_ni:  0.000395681
p_wrong:  0.000296056
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.998326878
p_ni:  0.001111002
p_wrong:  0.000562121
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Choline catabolism (R-HSA-6798163)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Choline catabolism
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Choline catabolism
Glycerophospholipid biosynthesis
Metabolism
Metabolism of amino acids and derivatives
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
2
2
58.9
BMI-adjusted waist-hip ratio
1
2
2
55.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
58.9
BMI-adjusted waist-hip ratio
2
55.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 44 member 1
VGNC:13965
464632
Macaque
solute carrier family 44 member 1
715816
Mouse
MGI:2140592
100434
Rat
RGD:621426
85254
Dog
solute carrier family 44 member 1
VGNC:46417
474792
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 44 member 1
Macaque
solute carrier family 44 member 1
Mouse
Rat
Dog
solute carrier family 44 member 1
Publication Statistics
PubMed Score 74.28
PubMed score by year
PubTator Score 39.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title