LMO7
LIM domain only protein 7
Protein Summary
This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009]
- ENST00000341547
- ENSP00000342112
- ENSG00000136153
- FBX20
- FBXO20
- KIAA0858
- LOMP
- FBX20
- LMO7b
- FBXO20
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.96 | ||
ligand (protein) perturbation | 0.96 | ||
virus perturbation | 0.94 | ||
interacting protein | 0.76 | ||
hub protein | 0.75 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.18 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.18 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (4)
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1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
intraocular pressure measurement | 4 | 5 | 5 | 90 | |||||
1 | 1 | 0 | 1.1 | 61.6 | |||||
1 | 1 | 0 | 1.4 | 58.6 | |||||
1 | 1 | 0 | 1.1 | 29.9 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
intraocular pressure measurement | 5 | 90 | |||||
0 | 1.1 | 61.6 | |||||
0 | 1.4 | 58.6 | |||||
0 | 1.1 | 29.9 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | LIM domain 7 | VGNC:13124 | 452604 | |||||
Macaque | LIM domain 7 | 697648 | ||||||
Mouse | MGI:1353586 | 380928 | ||||||
Rat | RGD:1302984 | 361084 | ||||||
Dog | LIM domain 7 | VGNC:42725 | 476948 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | LIM domain 7 | |||||
Macaque | LIM domain 7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | LIM domain 7 | |||||
Protein Structure (1 Structure, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (8)
Reactome (7)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Immune System | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Immune System | ||||
Metabolism of proteins | ||||
Gene Ontology Terms (17)
Functions (3)
Components (8)
Processes (6)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (380)
1 – 10 of 380
COMMD6
Novelty: 0.11854363
Score: 0.979
Data Source: STRINGDB
ASB11
Novelty: 0.84862254
Score: 0.94
Data Source: STRINGDB
SKP1
Family: Enzyme
Novelty: 0.00149739
Score: 0.939
Data Source: STRINGDB
FBXL13
Novelty: 0.33362589
Score: 0.936
Data Source: STRINGDB
WWP1
Family: Enzyme
Novelty: 0.01407874
Score: 0.935
Data Source: STRINGDB
FBXL7
Novelty: 0.10670779
Score: 0.932
Data Source: STRINGDB
UBC
Novelty: 0.00204643
Score: 0.932
Data Source: STRINGDB
FBXL15
Novelty: 0.18567032
Score: 0.932
Data Source: STRINGDB
CUL3
Novelty: 0.0028737
Score: 0.931
Data Source: STRINGDB
FBXL14
Novelty: 0.21211079
Score: 0.931
Data Source: STRINGDB
Publication Statistics
PubMed Score 32.18
PubMed score by year
PubTator Score 12.06
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword