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Tbio
LMO7
LIM domain only protein 7

Protein Summary
Description
This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341547
  • ENSP00000342112
  • ENSG00000136153

Symbol
  • FBX20
  • FBXO20
  • KIAA0858
  • LOMP
  • FBX20
  • LMO7b
  • FBXO20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
ligand (protein) perturbation
0.96
virus perturbation
0.94
interacting protein
0.76
hub protein
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.18   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.18   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
5
5
90
1
1
0
1.1
61.6
1
1
0
1.4
58.6
1
1
0
1.1
29.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
90
0
1.1
61.6
0
1.4
58.6
0
1.1
29.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM domain 7
VGNC:13124
452604
Macaque
LIM domain 7
697648
Mouse
MGI:1353586
380928
Rat
RGD:1302984
361084
Dog
LIM domain 7
VGNC:42725
476948
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM domain 7
Macaque
LIM domain 7
Mouse
Rat
Dog
LIM domain 7
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WWI1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Protein-Protein Interactions (380)
1 – 10 of 380
COMMD6
Tbio
Novelty: 0.11854363
Score: 0.979
Data Source: STRINGDB
ASB11
Tdark
Novelty: 0.84862254
Score: 0.94
Data Source: STRINGDB
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
Score: 0.939
Data Source: STRINGDB
FBXL13
Tdark
Novelty: 0.33362589
Score: 0.936
Data Source: STRINGDB
WWP1
Tbio
Family: Enzyme
Novelty: 0.01407874
Score: 0.935
Data Source: STRINGDB
FBXL7
Tbio
Novelty: 0.10670779
Score: 0.932
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.932
Data Source: STRINGDB
FBXL15
Tbio
Novelty: 0.18567032
Score: 0.932
Data Source: STRINGDB
CUL3
Tbio
Novelty: 0.0028737
Score: 0.931
Data Source: STRINGDB
FBXL14
Tbio
Novelty: 0.21211079
Score: 0.931
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.18

PubMed score by year
PubTator Score  12.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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