TRUB1
Probable tRNA pseudouridine synthase 1
Protein Summary
Pseudouridine synthase that catalyzes pseudouridylation of mRNAs (PubMed:28073919). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).[supplied by OMIM, Mar 2008]
- ENST00000298746
- ENSP00000298746
- ENSG00000165832
- PUS4
- PUS4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.86 | ||
histone modification site profile | 0.65 | ||
tissue sample | 0.65 | ||
transcription factor binding site profile | 0.65 | ||
tissue | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.54 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 112 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.54 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 112 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (241)
SLC2A2
Family: Transporter
Novelty: 0.00103579
p_int: 0.996628268
p_ni: 0.003369291
p_wrong: 0.000002441
Score: 0.54
Data Source: BioPlex,STRINGDB
MTFMT
Family: Enzyme
Novelty: 0.011101
p_int: 0.99644252
p_ni: 0.000001051
p_wrong: 0.003556429
Score: 0.755
Data Source: BioPlex,STRINGDB
USP11
Family: Enzyme
Novelty: 0.03397914
p_int: 0.860875108
p_ni: 0.139124892
Score: 0.862
Data Source: BioPlex,STRINGDB
TCEAL1
Novelty: 0.02210924
p_int: 0.763495657
p_ni: 0.236504343
Score: 0.622
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 2 | 2 | 1 | 5.9 | 78.7 | ||||
lifestyle measurement | 1 | 1 | 1 | 39.6 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 1 | 5.9 | 78.7 | ||||
lifestyle measurement | 1 | 39.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | TruB pseudouridine synthase family member 1 | VGNC:9779 | 466209 | |||||
Macaque | TruB pseudouridine synthase family member 1 | 699133 | ||||||
Mouse | MGI:1919383 | 72133 | ||||||
Rat | RGD:1308502 | 361775 | ||||||
Dog | TruB pseudouridine synthase family member 1 | VGNC:47888 | 486900 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | TruB pseudouridine synthase family member 1 | |||||
Macaque | TruB pseudouridine synthase family member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | TruB pseudouridine synthase family member 1 | |||||
Publication Statistics
PubMed Score 15.54
PubMed score by year
PubTator Score 4.17
PubTator score by year
Related Publications
Text Mined References (8)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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