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Tbio
TRUB1
Probable tRNA pseudouridine synthase 1

Protein Summary
Description
Pseudouridine synthase that catalyzes pseudouridylation of mRNAs (PubMed:28073919). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298746
  • ENSP00000298746
  • ENSG00000165832

Symbol
  • PUS4
  • PUS4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.86
histone modification site profile
0.65
tissue sample
0.65
transcription factor binding site profile
0.65
tissue
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.54   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.54   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (241)
SLC2A2
Tchem
Family:  Transporter
Novelty:  0.00103579
p_int:  0.996628268
p_ni:  0.003369291
p_wrong:  0.000002441
Score:  0.54
Data Source:  BioPlex,STRINGDB
MTFMT
Tbio
Family:  Enzyme
Novelty:  0.011101
p_int:  0.99644252
p_ni:  0.000001051
p_wrong:  0.003556429
Score:  0.755
Data Source:  BioPlex,STRINGDB
USP11
Tbio
Family:  Enzyme
Novelty:  0.03397914
p_int:  0.860875108
p_ni:  0.139124892
Score:  0.862
Data Source:  BioPlex,STRINGDB
TCEAL1
Tbio
Novelty:  0.02210924
p_int:  0.763495657
p_ni:  0.236504343
Score:  0.622
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
GAR1
Tbio
Novelty:  0.26091307
Score:  0.955
Data Source:  STRINGDB
NHP2
Tbio
Novelty:  0.01414024
Score:  0.953
Data Source:  STRINGDB
PUS1
Tbio
Family:  Enzyme
Novelty:  0.01923618
Score:  0.94
Data Source:  STRINGDB
DDX55
Tdark
Family:  Enzyme
Novelty:  0.27887497
Score:  0.938
Data Source:  STRINGDB
NOP56
Tbio
Novelty:  0.01256937
Score:  0.933
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
5.9
78.7
lifestyle measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
5.9
78.7
lifestyle measurement
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TruB pseudouridine synthase family member 1
VGNC:9779
466209
Macaque
TruB pseudouridine synthase family member 1
699133
Mouse
MGI:1919383
72133
Rat
RGD:1308502
361775
Dog
TruB pseudouridine synthase family member 1
VGNC:47888
486900
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TruB pseudouridine synthase family member 1
Macaque
TruB pseudouridine synthase family member 1
Mouse
Rat
Dog
TruB pseudouridine synthase family member 1
Publication Statistics
PubMed Score 15.54
PubMed score by year
PubTator Score 4.17
PubTator score by year
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Related Publications
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PMID
Year
Title