You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ASZ1
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1

Protein Summary
Description
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284629
  • ENSP00000284629
  • ENSG00000154438

Symbol
  • ALP1
  • ANKL1
  • C7orf7
  • GASZ
  • ALP1
  • GASZ
  • Orf3
  • ANKL1
  • C7orf7
  • CT1.19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
virus perturbation
0.55
cell line
0.54
biological process
0.51
PubMedID
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 917.08   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 917.08   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
MOV10L1
Tbio
Family:  Enzyme
Novelty:  0.09735465
Score:  0.983
Data Source:  STRINGDB
MAEL
Tbio
Novelty:  0.01925239
Score:  0.98
Data Source:  STRINGDB
TDRD9
Tbio
Family:  Epigenetic
Novelty:  0.10913126
Score:  0.977
Data Source:  STRINGDB
TDRD1
Tbio
Family:  Epigenetic
Novelty:  0.04645566
Score:  0.977
Data Source:  STRINGDB
HENMT1
Tdark
Family:  Enzyme
Novelty:  0.17427834
Score:  0.968
Data Source:  STRINGDB
FKBP6
Tbio
Family:  Enzyme
Novelty:  0.02240256
Score:  0.959
Data Source:  STRINGDB
TDRKH
Tbio
Family:  Epigenetic
Novelty:  0.0875409
Score:  0.959
Data Source:  STRINGDB
PIWIL2
Tbio
Novelty:  0.00907402
Score:  0.958
Data Source:  STRINGDB
DDX4
Tbio
Family:  Enzyme
Novelty:  0.00692586
Score:  0.956
Data Source:  STRINGDB
PIWIL4
Tbio
Novelty:  0.00105088
Score:  0.954
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
PIWI-interacting RNA (piRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
PIWI-interacting RNA (piRNA) biogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
3
4
86
BMI-adjusted waist-hip ratio
3
3
4
85.3
1
1
0
1.2
28.1
Dupuytren Contracture
1
1
0
1.2
17.8
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
4
86
BMI-adjusted waist-hip ratio
4
85.3
0
1.2
28.1
Dupuytren Contracture
0
1.2
17.8
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat, SAM and basic leucine zipper domain containing 1
VGNC:7215
450111
Macaque
ankyrin repeat, SAM and basic leucine zipper domain containing 1
705097
Mouse
MGI:1921318
74068
Rat
RGD:621579
170578
Dog
ankyrin repeat, SAM and basic leucine zipper domain containing 1
VGNC:38199
610199
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat, SAM and basic leucine zipper domain containing 1
Macaque
ankyrin repeat, SAM and basic leucine zipper domain containing 1
Mouse
Rat
Dog
ankyrin repeat, SAM and basic leucine zipper domain containing 1
Publication Statistics
PubMed Score 917.08
PubMed score by year
PubTator Score 305.38
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title