You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KCNE4
Potassium voltage-gated channel subfamily E member 4

Protein Summary
Description
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, J ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281830
  • ENSP00000281830
  • ENSG00000152049

Symbol
  • MIRP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
molecular function
0.76
cell line
0.71
microRNA
0.64
tissue sample
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.21   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.21   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 2 - plateau phase
Reactome
Phase 3 - rapid repolarisation
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 2 - plateau phase
Phase 3 - rapid repolarisation
Protein-Protein Interactions (51)
1 – 10 of 51
KCNQ1
Tclin
Family: IC
Novelty: 0.00103494
Score: 0.978
Data Source: STRINGDB
KCNH2
Tclin
Family: IC
Novelty: 0.00059104
Score: 0.952
Data Source: STRINGDB
AKAP9
Tbio
Family: Enzyme
Novelty: 0.0055702
Score: 0.93
Data Source: STRINGDB
KCNE2
Tbio
Family: IC
Novelty: 0.00983934
Score: 0.842
Data Source: STRINGDB
KCNE3
Tbio
Family: IC
Novelty: 0.021408
Score: 0.828
Data Source: STRINGDB
CAMLG
Tbio
Novelty: 0.01056088
Score: 0.808
Data Source: STRINGDB
KCNE5
Tbio
Novelty: 0.1013269
Score: 0.802
Data Source: STRINGDB
KCNE1
Tbio
Family: IC
Novelty: 0.00199157
Score: 0.778
Data Source: STRINGDB
KCNC4
Tclin
Family: IC
Novelty: 0.01722039
Score: 0.746
Data Source: STRINGDB
KCNQ4
Tclin
Family: IC
Novelty: 0.00818066
Score: 0.742
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.21

PubMed score by year
PubTator Score  14.5

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer