You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TMED6
Transmembrane emp24 domain-containing protein 6

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288025
  • ENSP00000288025
  • ENSG00000157315

Symbol
  • p24g5
  • PRO34237
  • SPLL9146
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
tissue sample
0.54
cell line
0.47
virus perturbation
0.45
cellular component
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.83   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.83   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
76
triglyceride measurement
1
1
1
7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
76
triglyceride measurement
1
7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane p24 trafficking protein 6
744308
Macaque
transmembrane p24 trafficking protein 6
704771
Mouse
MGI:1913519
66269
Rat
RGD:1305260
291991
Dog
transmembrane p24 trafficking protein 6
610951
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane p24 trafficking protein 6
Macaque
transmembrane p24 trafficking protein 6
Mouse
Rat
Dog
transmembrane p24 trafficking protein 6
Gene Ontology Terms (9)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (75)
1 – 10 of 75
ALG9
Tbio
Family: Enzyme
Novelty: 0.02975572
p_int: 0.998312187
p_ni: 0.001687763
p_wrong: 5e-8
Data Source: BioPlex
SMPD2
Tchem
Family: Enzyme
Novelty: 0.00375744
p_int: 0.997399201
p_ni: 0.002600772
p_wrong: 2.7e-8
Data Source: BioPlex
VEZT
Tbio
Novelty: 0.06274137
p_int: 0.997033216
p_ni: 0.00286461
p_wrong: 0.000102174
Data Source: BioPlex
LRP12
Tbio
Novelty: 0.11426952
p_int: 0.995702563
p_ni: 0.00429698
p_wrong: 4.57e-7
Data Source: BioPlex
ATP2A3
Tbio
Family: Transporter
Novelty: 0.0090982
p_int: 0.994286868
p_ni: 0.005713132
Data Source: BioPlex
ITGA2
Tbio
Novelty: 0.0013482
p_int: 0.992596317
p_ni: 0.007268902
p_wrong: 0.000134782
Data Source: BioPlex
C1QL1
Tdark
Novelty: 0.11689088
p_int: 0.983141385
p_ni: 0.016065744
p_wrong: 0.000792871
Data Source: BioPlex
BTN2A2
Tdark
Novelty: 0.46565474
p_int: 0.980513264
p_ni: 0.019486736
Data Source: BioPlex
CNTNAP3B
Tdark
Novelty: 0.25889644
p_int: 0.97915184
p_ni: 0.020848159
p_wrong: 1e-9
Data Source: BioPlex
CNNM1
Tdark
Novelty: 0.11053515
p_int: 0.97490492
p_ni: 0.023806154
p_wrong: 0.001288926
Data Source: BioPlex
Publication Statistics
PubMed Score  1.83

PubMed score by year
PubTator Score  0.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer