You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
APH1B
Gamma-secretase subunit APH-1B

Protein Classes
Protein Summary
Description
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261879
  • ENSP00000261879
  • ENSG00000138613
  • ENST00000380343
  • ENSP00000369700

Symbol
  • PSFL
  • PSFL
  • APH-1B
  • PRO1328
  • TAAV688
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
disease perturbation
0.68
tissue sample
0.68
transcription factor perturbation
0.68
cellular component
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.29   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.29   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
2
1
7.5
89.5
Myopia
2
2
0
4.3
63.2
glomerular filtration rate
2
1
2
56.8
age at onset
1
1
0
7.5
47.8
1
1
0
5.5
26.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
7.5
89.5
Myopia
0
4.3
63.2
glomerular filtration rate
2
56.8
age at onset
0
7.5
47.8
0
5.5
26.8
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aph-1 homolog B, gamma-secretase subunit
VGNC:6598
467700
Macaque
aph-1 homolog B, gamma-secretase subunit
705718
Mouse
MGI:1915568
68318
Dog
aph-1 homolog B, gamma-secretase subunit [Source:HGNC Symbol;Acc:HGNC:24080]
Horse
aph-1 homolog B, gamma-secretase subunit
VGNC:15407
100067205
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aph-1 homolog B, gamma-secretase subunit
Macaque
aph-1 homolog B, gamma-secretase subunit
Mouse
Dog
aph-1 homolog B, gamma-secretase subunit [Source:HGNC Symbol;Acc:HGNC:24080]
Horse
aph-1 homolog B, gamma-secretase subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WW43-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (87)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Amyloid fiber formation
Reactome
Axon guidance
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Amyloid fiber formation
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (57)
1 – 10 of 57
PSEN1
Tchem
Family: Enzyme
Novelty: 0.00024189
Score: 0.999
Data Source: Reactome,STRINGDB
NCSTN
Tbio
Novelty: 0.00453935
Score: 0.999
Data Source: Reactome,STRINGDB
PSEN2
Tchem
Family: Enzyme
Novelty: 0.00112188
Score: 0.999
Data Source: Reactome,STRINGDB
PSENEN
Tchem
Family: Enzyme
Novelty: 0.00118125
Score: 0.999
Data Source: Reactome,STRINGDB
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.957
Data Source: STRINGDB
DLL1
Tbio
Novelty: 0.00150384
Score: 0.936
Data Source: STRINGDB
NOTCH3
Tchem
Novelty: 0.000953
Score: 0.935
Data Source: STRINGDB
NOTCH2
Tchem
Novelty: 0.00195617
Score: 0.929
Data Source: STRINGDB
DLL4
Tbio
Novelty: 0.00263355
Score: 0.923
Data Source: STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.29

PubMed score by year
PubTator Score  10.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer