Tbio APH1B Gamma-secretase subunit APH-1B

Protein Summary

Description

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q8WW43
• A8K589
• Q564N3
• Q6UWQ1
• Q9H0S0
• APH-1b

Gene Name

• APH1B

Ensembl ID

• ENST00000261879
• ENSP00000261879
• ENSG00000138613
• ENST00000380343
• ENSP00000369700

Symbol

• PSFL
• PSFL
• APH-1B
• PRO1328
• TAAV688

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
disease perturbation	0.68
tissue sample	0.68
transcription factor perturbation	0.68
cellular component	0.65

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Gamma-secretase Subunit Aph-1b

DTO Classes

Protein / Enzyme Modulator / Gamma-secretase Subunit Aph-1b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.2   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 68   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.2   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0